巨噬细胞衍生的多核巨细胞：衰老卵巢的特征。
Macrophage-derived multinucleated giant cells: hallmarks of the aging ovary.
机构信息
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.
出版信息
Reproduction. 2021 Feb;161(2):V5-V9. doi: 10.1530/REP-20-0489.
Abstract
Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.
摘要
炎症衰老是一种与衰老相关的慢性、低度炎症状态，可导致与年龄相关的疾病。最近，人们在哺乳动物的卵巢中发现了与年龄相关的炎症增加，同时免疫细胞的特征也发生了转变。在这篇观点文章中，我们认为在生殖衰老的小鼠卵巢中发现的一种独特的巨噬细胞衍生的多核巨细胞群体，可能是卵巢衰老过程中炎症的潜在标志物或功能驱动因素。
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