Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University, Halle, Germany.
PLoS One. 2020 Dec 1;15(12):e0242807. doi: 10.1371/journal.pone.0242807. eCollection 2020.
The aim of this study was to assess the magnitude, socio-demographic, and clinical characteristics of oesophageal cancer patients in selected referral hospitals of Ethiopia. A retrospective document review was employed in ten referral hospitals in different regions of Ethiopia. A structured data extraction tool was used to extract data from clinical care records of all clinically and pathologically confirmed oesophageal cancer patients who were diagnosed and treated in those hospitals from 2012 to 2017. During the study period, a total of 777 oesophageal cancer cases were identified, and the median age of these patients was 55 years, with an interquartile range of 19. More than half (55.1%, n = 428) of the cases were males, and the majority of them were reported from Oromia (49.9%, n = 388) and Somali (25.9%, n = 202) regional states. The highest numbers of oesophageal cancer cases were recorded in 2016 (23.8%, n = 185), while the lowest were in 2012 (12.6%, n = 98). Eighty per cent of oesophageal cancer cases were diagnosed in later stages of the disease. More than one-fourth (27.0%, n = 210) of patients had surgical procedures where the majority (74.3%, n = 156) required insertion of a feeding tube followed by transhiatal oesophagectomy (10.9%, n = 23). Of the 118 patients for which there was histology data, squamous cell carcinoma (56.7%, n = 67) and adenocarcinoma (36.4%, n = 43) were the predominant histologic type. One-fourth (25.0%, n = 194) of the patients were alive, and more than two-thirds (71.7%, n = 557) of the patients' current status was unknown at the time of the review. In these referral hospitals of Ethiopia, many oesophageal cancer patients presented during later stages of the disease and needed palliative care measures. The number of patients seen in Oromia and Somali hospitals by far exceeded hospitals of the other regions, thus postulating possibly unique risk factors in those geographic areas.
本研究旨在评估埃塞俄比亚选定转诊医院的食管癌患者的严重程度、社会人口学和临床特征。在埃塞俄比亚不同地区的十家转诊医院中采用了回顾性文件审查。使用结构化数据提取工具从 2012 年至 2017 年在这些医院被诊断和治疗的所有经临床和病理证实的食管癌患者的临床护理记录中提取数据。在研究期间,共发现 777 例食管癌病例,这些患者的中位年龄为 55 岁,四分位间距为 19。超过一半(55.1%,n=428)的病例为男性,其中大多数来自奥罗米亚(49.9%,n=388)和索马里(25.9%,n=202)地区。2016 年记录的食管癌病例数最高(23.8%,n=185),而 2012 年记录的病例数最低(12.6%,n=98)。80%的食管癌病例在疾病的晚期被诊断出来。超过四分之一(27.0%,n=210)的患者接受了手术治疗,其中大多数(74.3%,n=156)需要插入饲管,随后进行经食管裂孔切除术(10.9%,n=23)。在有组织学数据的 118 名患者中,鳞状细胞癌(56.7%,n=67)和腺癌(36.4%,n=43)是主要的组织学类型。四分之一(25.0%,n=194)的患者仍然存活,而在审查时,超过三分之二(71.7%,n=557)的患者目前状况未知。在埃塞俄比亚的这些转诊医院中,许多食管癌患者在疾病的晚期出现,并需要姑息治疗措施。奥罗米亚和索马里医院的患者人数远远超过其他地区的医院,因此可以推测这些地理区域可能存在独特的危险因素。