在塞尔维亚，被硬蜱（Ixodes ricinus）寄生的人类会接触到各种各样的蜱媒病原体。
Humans infested with Ixodes ricinus are exposed to a diverse array of tick-borne pathogens in Serbia.
机构信息
Ambulance for Lyme Borreliosis and Other Tick-Borne Diseases, Pasteur Institute Novi Sad, Novi Sad 21000, Serbia; University of Novi Sad, Medical Faculty Novi Sad, Department of Microbiology with Parasitology and Immunology. Hajduk Veljkova 1-3, Novi Sad, Serbia.
Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada.
出版信息
Ticks Tick Borne Dis. 2021 Mar;12(2):101609. doi: 10.1016/j.ttbdis.2020.101609. Epub 2020 Nov 23.
Tick-borne pathogens (TBPs) pose a major threat to human health in Europe and the whole northern hemisphere. Despite a high prevalence of TBPs in Ixodes ricinus ticks, knowledge on the incidence of tick-borne diseases in humans infested by this tick species is limited. This study was conducted in the year 2019 on patients who presented themselves to the Pasteur Institute Novi Sad with tick infestations. Ticks (n = 31) feeding on human (n = 30) and blood samples from the same individuals were collected by physicians and a microfluidic real-time high-throughput PCR system was used to test the genomic DNA of the samples for the presence of 27 bacterial and eight parasitic microorganisms in Serbia. Except for one Rhipicephalus sanguineus s.l. adult male tick, all ticks infesting humans were morphologically identified as I. ricinus. A high proportion of ticks (74 %, 23/31) were infected with at least one of the tested TB microorganisms, being Rickettsia helvetica (54 %, 17/31) the most common pathogen, but Borrelia afzelii (9 %, 3/31), Anaplasma phagocytophilum (6 %, 2/31), Borrelia miyamotoi (6 %, 2/31), and Francisella like-endosymbiont (6 %, 2/31), Borrelia valaisiana (3 %, 1/31), Borrelia lusitaniae (3 %, 1/31), Rickettsia felis (3 %, 1/31) and Rickettsia aeschlimannii (3 %, 1/31) were also identified. Despite the high infection rate of TBPs in ticks, only two human blood samples (6 %, 2/30) tested positive for the presence of TBPs, one patient (code H12, 67 years old female) was diagnosed with Borrelia spp. and the other patient was diagnosed (code H17, 71 years old female) with R. felis infection. The tick infesting patient H12 tested positive for B. afzelii, and R. helvetica and the tick infesting patient H17 tested positive for R. felis. Upon clinical examination, both patients were diagnosed with erythema migrans. No additional discomfort was reported by the patient and no additional pathology was observed by the physician. We concluded that humans bitten by I. ricinus in Serbia are exposed to a diverse array of TBPs with clinical impact in the Serbian cohort studied.
蜱传病原体（TBPs）对欧洲和整个北半球的人类健康构成重大威胁。尽管在硬蜱中普遍存在 TBPs，但关于被这种蜱类寄生的人类 tick-borne 疾病的发病率知之甚少。本研究于 2019 年在因 tick 感染而前往诺维萨德巴斯德研究所就诊的患者中进行。医生采集了 31 只吸食人类（n = 30）和来自同一人的血液样本，并使用微流控实时高通量 PCR 系统检测样本的基因组 DNA 中塞尔维亚 27 种细菌和 8 种寄生虫微生物的存在情况。除了一只 Rhipicephalus sanguineus s.l. 成年雄性蜱外，所有寄生人类的蜱均通过形态学鉴定为 I. ricinus。相当比例的蜱（74%，23/31）至少感染了一种测试的 TB 微生物，其中最常见的病原体是汉塞巴尔通体（54%，17/31），但伯氏疏螺旋体（9%，3/31）、嗜吞噬细胞无形体（6%，2/31）、米氏巴贝西虫（6%，2/31）和弗朗西斯菌样内共生体（6%，2/31），瓦莱州疏螺旋体（3%，1/31）、莱姆病螺旋体（3%，1/31）、猫立克次体（3%，1/31）和阿氏疏螺旋体（3%，1/31）也被鉴定出来。尽管蜱中 TBPs 的感染率很高，但只有两份人类血液样本（6%，2/30）检测出 TBPs 阳性，一名患者（代码 H12，67 岁女性）被诊断为伯氏疏螺旋体，另一名患者（代码 H17，71 岁女性）被诊断为猫立克次体感染。寄生患者 H12 的蜱检测出伯氏疏螺旋体和汉塞巴尔通体阳性，寄生患者 H17 的蜱检测出猫立克次体阳性。临床检查发现，两名患者均被诊断为游走性红斑。患者没有报告其他不适，医生也没有观察到其他病理。我们得出的结论是，在塞尔维亚，被 I. ricinus 叮咬的人类接触到具有临床影响的多种 TBPs。
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