Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.
Department of Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Digestion. 2021;102(5):731-741. doi: 10.1159/000511851. Epub 2020 Dec 1.
Colonic motility disorders are a frequent clinical problem caused by various drugs and diseases. However, the etiology of colonic dysmotility is often unclear due to the lack of in vivo methods, including rapid dynamic assessment.
The aim of this study was to establish a novel quantitative method to objectively assess colonic motility using ultrasonography.
We applied echocardiographic speckle tracking-based strain imaging to analyze murine colonic motility. A trace line was placed on the boundary between the proximal wall of the colon and the inner cavity to analyze colonic wall displacement and strain rate. Locomotion activities of the colonic wall were used to quantify colonic motility via ultrasonography.
We found that ultrasonography can quantitatively detect a decrease in colonic motility induced by loperamide, an antidiarrheal drug. These quantitative data were consistent with the imaging findings of colonic peristalsis and colon transit time. Additionally, ultrasonography also revealed changes in colonic motility over short intervals. Furthermore, we have shown that ultrasonography can quantitatively and noninvasively detect colonic dysmotility and hypervascularity of the colonic wall in colitis mice.
These findings suggest that ultrasonography is a useful in vivo method for objectively monitoring changes in colonic motility caused by drugs and diseases.
肠道动力障碍是由各种药物和疾病引起的常见临床问题。然而，由于缺乏体内方法，包括快速动态评估，肠道动力障碍的病因往往不清楚。
本研究旨在建立一种新的定量方法，使用超声技术客观评估肠道动力。
我们应用基于超声心动图斑点追踪的应变成像来分析小鼠的结肠动力。在结肠近端壁和内腔之间的边界上放置一条轨迹线，以分析结肠壁的位移和应变速率。通过超声检测结肠壁的运动活动来定量评估肠道运动。
我们发现超声可以定量检测出洛哌丁胺（一种止泻药）引起的肠道运动减少。这些定量数据与结肠蠕动和结肠通过时间的影像学发现一致。此外，超声还揭示了短时间内肠道运动的变化。此外，我们还表明，超声可以定量和无创地检测结肠炎小鼠的结肠动力障碍和结肠壁的高血管化。
这些发现表明，超声是一种有用的体内方法，可以客观监测药物和疾病引起的肠道动力变化。
