Zhang Nan, Scarsella Joseph B, Hartman Thomas G
Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901, USA.
Polymers (Basel). 2020 Nov 29;12(12):2846. doi: 10.3390/polym12122846.
Bisphenol A (BPA)-based epoxy resins have wide applications as food-contact materials such as metal can coatings. However, negative consumer perceptions toward BPA have driven the food packaging industry to develop other alternatives. In this study, four different metal cans and their lids manufactured with different BPA-replacement food-contact coatings are subjected to migration testing in order to identify migratory chemical species from the coatings. Migration tests are conducted using food simulants and conditions of use corresponding to the intended applications and regulatory guidance from the U.S. Food and Drug Administration. Extracts are analyzed by gas chromatography mass spectrometry (GC-MS) and high resolution GC-MS. The migratory compounds identified include short chain cyclic polyester migrants from polyester-based coatings and bisphenol-type migrants including tetramethyl bisphenol F (TMBPF), tetramethyl bisphenol F diglycidyl ether (TMBPF DGE), bisphenol F (BPF), bisphenol C (BPC), and other related monomers or oligomers. The concentration of the migrants is estimated using an internal standard, and validated trimethylsilyl (TMS) derivatization GC-MS methods are developed to specifically quantify TMBPF, BPF, BPC, and BPA in the coatings. The results will aid the safety evaluation of new food-contact material coating technology based on TMBPF chemistry and will provide an important reference for the industry in identifying and quantifying non-BPA coating-borne migrants.
基于双酚A（BPA）的环氧树脂作为食品接触材料有着广泛应用，如金属罐涂层。然而，消费者对BPA的负面认知促使食品包装行业开发其他替代品。在本研究中，对四种用不同BPA替代型食品接触涂层制造的不同金属罐及其盖子进行迁移测试，以确定涂层中的迁移化学物质。迁移测试使用食品模拟物以及与预期应用和美国食品药品监督管理局的监管指南相对应的使用条件来进行。提取物通过气相色谱 - 质谱联用仪（GC - MS）和高分辨率GC - MS进行分析。鉴定出的迁移化合物包括来自聚酯基涂层的短链环状聚酯迁移物以及双酚型迁移物，包括四甲基双酚F（TMBPF）、四甲基双酚F二缩水甘油醚（TMBPF DGE）、双酚F（BPF）、双酚C（BPC）以及其他相关单体或低聚物。使用内标估计迁移物的浓度，并开发经过验证的三甲基硅烷基（TMS）衍生化GC - MS方法来专门定量涂层中的TMBPF、BPF、BPC和BPA。研究结果将有助于基于TMBPF化学的新型食品接触材料涂层技术的安全性评估，并将为该行业识别和定量非BPA涂层携带的迁移物提供重要参考。
