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超支化水溶性β-环糊精聚合物的合成与表征。

Synthesis and characterization of a hyper-branched water-soluble β-cyclodextrin polymer.

机构信息

Dipartimento di Chimica, Università di Torino, Via Pietro Giuria 7, 10125 Torino, Italy.

Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via Pietro Giuria 9, 10125 Torino, Italy.

出版信息

Beilstein J Org Chem. 2014 Nov 6;10:2586-93. doi: 10.3762/bjoc.10.271. eCollection 2014.

DOI:10.3762/bjoc.10.271
PMID:25550720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4273288/
Abstract

A new hyper-branched water-soluble polymer was synthesized by reacting β-cyclodextrin with pyromellitic dianhydride beyond the critical conditions that allow the phenomenon of gelation to occur. The molar ratio between the monomers is a crucial parameter that rules the gelation process. Nevertheless, the concentration of monomers in the solvent phase plays a key role as well. Hyper-branched β-cyclodextrin-based polymers were obtained performing the syntheses with excess of solvent and cross-linking agent, and the conditions for critical dilution were determined experimentally. A hyper-branched polymer with very high water solubility was obtained and fully characterized both as for its chemical structure and for its capability to encapsulate substances. Fluorescein was used as probe molecule to test the complexation properties of the new material.

摘要

一种新型超支化水溶性聚合物是通过在β-环糊精与均苯四酸二酐反应时超越发生凝胶化现象的临界条件来合成的。单体之间的摩尔比是控制凝胶化过程的关键参数。然而，溶剂相中的单体浓度也起着关键作用。通过在过量的溶剂和交联剂存在下进行合成，可以得到超支化β-环糊精基聚合物，并通过实验确定了临界稀释条件。获得了一种具有非常高水溶性的超支化聚合物，并对其化学结构及其包封物质的能力进行了全面表征。使用荧光素作为探针分子来测试新材料的络合性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/d281116afc7a/Beilstein_J_Org_Chem-10-2586-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/b4198471ef9e/Beilstein_J_Org_Chem-10-2586-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/36e71d52a507/Beilstein_J_Org_Chem-10-2586-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/82a9ce501bff/Beilstein_J_Org_Chem-10-2586-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/53a9ce1d05e7/Beilstein_J_Org_Chem-10-2586-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/ec7076f6cd7a/Beilstein_J_Org_Chem-10-2586-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/8c0b8d805800/Beilstein_J_Org_Chem-10-2586-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/d281116afc7a/Beilstein_J_Org_Chem-10-2586-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/b4198471ef9e/Beilstein_J_Org_Chem-10-2586-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/36e71d52a507/Beilstein_J_Org_Chem-10-2586-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/82a9ce501bff/Beilstein_J_Org_Chem-10-2586-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/53a9ce1d05e7/Beilstein_J_Org_Chem-10-2586-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/ec7076f6cd7a/Beilstein_J_Org_Chem-10-2586-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/8c0b8d805800/Beilstein_J_Org_Chem-10-2586-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e69b/4273288/d281116afc7a/Beilstein_J_Org_Chem-10-2586-g008.jpg

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