T细胞在实验性小鼠球孢子菌病抗性中的意义。
Significance of T cells in resistance to experimental murine coccidioidomycosis.
作者信息
Beaman L, Pappagianis D, Benjamini E
出版信息
Infect Immun. 1977 Sep;17(3):580-5. doi: 10.1128/iai.17.3.580-585.1977.
Abstract
The resistance of mice to coccidioidomycosis was found to be dependent on lymphoid cells. Thus, spleen cells from mice immunized with killed spherules of Coccidioides immitis, when transferred to irradiated (500 R) recipients, conferred upon the recipient mice resistance to infection with C. immitis. Prior incubation of these spleen cells with anti-theta serum in the presence of complement abrogated their capacity to protect the recipients from infection with C. immitis. Adult thymectomized mice, which had been irradiated (800 R) and reconstituted with bone marrow from normal mice, were more susceptible to infection with arthrospores than were nonthymectomized, irradiated bone marrow-reconstituted controls. Genetically homozygous athymic ("nude") mice died after infection with a dose of arthrospores that was sublethal for their heterozygote counterparts possessing a thymus, or for normal mice. The results indicate that a functioning T-cell population is an essential component for effective immunity to C. immitis.
摘要
已发现小鼠对球孢子菌病的抵抗力取决于淋巴细胞。因此，用灭活的粗球孢子菌小球免疫的小鼠的脾细胞，转移到经辐射（500拉德）的受体小鼠后，能使受体小鼠获得对粗球孢子菌感染的抵抗力。在补体存在的情况下，将这些脾细胞与抗θ血清预先孵育，会消除它们保护受体小鼠免受粗球孢子菌感染的能力。成年去胸腺小鼠经辐射（800拉德）并用正常小鼠的骨髓重建后，比未去胸腺、经辐射并骨髓重建的对照小鼠更容易受到关节孢子感染。基因纯合的无胸腺（“裸”）小鼠在感染一定剂量的关节孢子后死亡，该剂量对具有胸腺的杂合子同窝小鼠或正常小鼠来说是亚致死剂量。结果表明，功能正常的T细胞群体是对粗球孢子菌产生有效免疫的重要组成部分。
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