小鼠对粗球孢子菌感染的抗性机制。
Mechanisms of resistance to infection with Coccidioides immitis in mice.
作者信息
Beaman L V, Pappagianis D, Benjamini E
出版信息
Infect Immun. 1979 Mar;23(3):681-5. doi: 10.1128/iai.23.3.681-685.1979.
Serum from vaccinated mice was ineffective in neutralizing the infectivity of arthrospores of Coccidioides immitis for recipient mice. However, a T-cell-enriched lymphocyte population was effective in preventing a lethal infection. Spleen cells from immune mice were passaged through nylon wool columns resulting in a T-cell enriched, B-cell-depleted population as shown by the susceptibility of the cell population to anti-theta serum and the inability of the cells to transfer adoptively an immune response to ovalbumin. Whereas transfer of 5 x 10(7) unfractionated immune spleen cells was required to protect 100% of the recipients against a lethal infection with C. immitis, 7 x 10(6) T-cell-enriched immune spleen cells were sufficient for the same level of protection. Thus, transfer of resistance to infection was achieved with fewer cells after the removal of B cells from the transferred spleen cells. The results confirm that T cells are crucial in transferring resistance against infection with C. immitis in mice.
接种疫苗小鼠的血清在中和粗球孢子菌关节孢子对受体小鼠的感染性方面无效。然而，富含T细胞的淋巴细胞群体在预防致死性感染方面有效。将免疫小鼠的脾细胞通过尼龙毛柱，得到一个富含T细胞、B细胞耗尽的群体，这通过细胞群体对抗θ血清的敏感性以及细胞不能将对卵清蛋白的免疫反应过继转移来证明。虽然需要转移5×10⁷个未分级的免疫脾细胞才能保护100%的受体免受粗球孢子菌的致死性感染，但7×10⁶个富含T细胞的免疫脾细胞就足以提供相同水平的保护。因此，从转移的脾细胞中去除B细胞后，用更少的细胞就实现了感染抗性的转移。结果证实，T细胞在转移小鼠对粗球孢子菌感染的抗性中起关键作用。
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