Sanaat Amirhossein, Ashrafi-Belgabad Aydin, Zaidi Habib
Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva 1211, Switzerland.
Physics and Energy Engineering Department, Amirkabir University of Technology, Tehran, Iran.
Phys Med Biol. 2020 Dec 2;65(23):235044. doi: 10.1088/1361-6560/abaeb8.
We propose and evaluate the performance of an improved preclinical positron emission tomography (PET) scanner design, referred to as Polaroid-PET, consisting of a detector equipped with a layer of horizontal Polaroid to filter scintillation photons with vertical polarization. This makes it possible to improve the spatial resolution of PET scanners based on monolithic crystals. First, a detector module based on a lutetium-yttrium orthosilicate monolithic crystal with 10 mm thickness and silicon photomultipliers (SiPMs) was implemented in the GEANT4 Monte Carlo toolkit. Subsequently, a layer of Polaroid was inserted between the crystal and the SiPMs. Two preclinical PET scanners based on ten detector modules with and without Polaroid were simulated. The performance of the proposed detector modules and corresponding PET scanner for the two configurations (with and without Polaroid) was assessed using standard performance parameters, including spatial resolution, sensitivity, optical photon ratio detected for positioning, and image quality. The detector module fitted with Polaroid led to higher spatial resolution (1.05 mm FWHM) in comparison with a detector without Polaroid (1.30 mm FHWM) for a point source located at the center of the detector module. From 100% of optical photons produced in the scintillator crystal, 65% and 66% were used for positioning in the detectors without and with Polaroid, respectively. Polaroid-PET resulted in higher axial spatial resolution (0.83 mm FWHM) compared to the scanner without Polaroid (1.01 mm FWHM) for a point source at the center of the field of view (CFOV). The absolute sensitivity at the CFOV was 4.37% and 4.31% for regular and Polaroid-PET, respectively. Planar images of a grid phantom demonstrated the potential of the detector with a Polaroid in distinguishing point sources located at close distances. Our results indicated that Polaroid-PET may improve spatial resolution by filtering the reflected optical photons according to their polarization state, while retaining the high sensitivity expected with monolithic crystal detector blocks.
我们提出并评估了一种改进的临床前正电子发射断层扫描(PET)扫描仪设计的性能,该设计称为宝丽来PET,它由一个配备有一层水平宝丽来的探测器组成,用于过滤具有垂直偏振的闪烁光子。这使得基于整块晶体的PET扫描仪的空间分辨率得以提高。首先,在GEANT4蒙特卡罗工具包中实现了一个基于厚度为10毫米的正硅酸镥钇整块晶体和硅光电倍增管(SiPM)的探测器模块。随后,在晶体和SiPM之间插入一层宝丽来。模拟了基于十个探测器模块的两种临床前PET扫描仪,一种有宝丽来,一种没有。使用包括空间分辨率、灵敏度、用于定位的检测到的光学光子比率和图像质量等标准性能参数,评估了所提出的探测器模块以及两种配置(有和没有宝丽来)下相应PET扫描仪的性能。对于位于探测器模块中心的点源,与没有宝丽来的探测器(半高宽为1.30毫米)相比,装有宝丽来的探测器模块导致更高的空间分辨率(半高宽为1.05毫米)。在闪烁晶体中产生的100%的光学光子中,分别有65%和66%用于没有宝丽来和有宝丽来的探测器中的定位。对于位于视野中心(CFOV)的点源,宝丽来PET与没有宝丽来的扫描仪(半高宽为1.01毫米)相比,轴向空间分辨率更高(半高宽为0.83毫米)。CFOV处的绝对灵敏度,常规PET为4.37%,宝丽来PET为4.31%。网格体模的平面图像展示了带有宝丽来的探测器在区分近距离点源方面的潜力。我们的结果表明,宝丽来PET可以通过根据反射光学光子的偏振状态对其进行过滤来提高空间分辨率,同时保持整块晶体探测器模块所期望的高灵敏度。