Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Department of Obstetrics, Gynecology, & Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA.
Epigenomics. 2021 Nov;13(21):1735-1746. doi: 10.2217/epi-2020-0007. Epub 2020 Dec 2.
We conducted a systematic review evaluating race/ethnicity representation in DNA methylomic studies of preterm birth. PubMed, EMBASE, CINHAL, Scopus and relevant citations from 1 January 2000 to 30 June 2019. Two authors independently identified abstracts comparing DNA methylomic differences between term and preterm births that included race/ethnicity data. 16 studies were included. Black and non-Hispanic Black deliveries were well represented (28%). However, large studies originating from more than 95% White populations were excluded due to unreported race/ethnicity data. Most studies were cross-sectional, allowing for reverse causation. Most studies were also racially/ethnically homogeneous, preventing direct comparison of DNA methylomic differences across race/ethnicities. In DNA methylomic studies, Black women and infants were well represented. However, the literature has limitations and precludes drawing definitive conclusions.
我们进行了一项系统评价，评估了种族/民族在早产的 DNA 甲基化组学研究中的代表性。检索了 2000 年 1 月 1 日至 2019 年 6 月 30 日期间的 PubMed、EMBASE、CINHAL、Scopus 和相关引文。两位作者独立识别了比较足月和早产出生之间 DNA 甲基化差异的摘要，这些摘要包括种族/民族数据。共纳入了 16 项研究。黑人及非西班牙裔黑人分娩的代表性很好（28%）。然而，由于未报告种族/民族数据，来自 95%以上白人人群的大型研究被排除在外。大多数研究是横断面研究，允许反向因果关系。大多数研究也是种族/民族同质的，这使得无法在不同种族/民族之间直接比较 DNA 甲基化差异。在 DNA 甲基化组学研究中，黑人妇女和婴儿的代表性很好。然而，该文献存在局限性，无法得出明确的结论。
