Paediatric Liver Unit including Intestinal Transplantation, Birmingham Women's and Children's NHS Foundation Trust, UK.
Institute of Diagnostic and Interventional Radiology, Department of Paediatric Radiology, Medizinische Hochschule Hannover, Germany.
J Pediatr Gastroenterol Nutr. 2021 Apr 1;72(4):487-493. doi: 10.1097/MPG.0000000000003006.
Diagnostic and therapeutic innovations have changed the way we now approach liver tumours in children and adolescents. Novel imaging tools, increasing awareness, and surveillance has led to early diagnosis of benign and malignant liver tumours. Multidisciplinary interventions have favourably altered the natural course in some liver tumours. The role of liver transplantation is expanding and has become fully integrated into today's therapeutic algorithms. Transarterial locoregional and ablation therapies have been successful in adults and are being explored in children to facilitate resectability and improve outcome. For the first time, North American, Japanese, and European experts have designed a global trial to optimize management of malignant liver tumours and aim to find signature molecular profiles that will translate to individualised treatment strategies.This article aims to offer an overview of recent advances in our understanding of liver tumours in children. It focuses on the paediatric hepatologist's view and their role in the multidisciplinary management of benign and malignant liver tumours.
诊断和治疗创新改变了我们现在治疗儿童和青少年肝肿瘤的方式。新的成像工具、不断提高的认识和监测导致了良性和恶性肝肿瘤的早期诊断。多学科干预在某些肝肿瘤的自然病程中产生了有利影响。肝移植的作用正在扩大，并已完全纳入当今的治疗算法。经肝动脉局部和消融治疗在成人中取得了成功，目前正在儿童中进行探索，以提高可切除性并改善预后。北美、日本和欧洲的专家首次设计了一项全球临床试验，旨在优化恶性肝肿瘤的治疗管理，并旨在找到将转化为个体化治疗策略的特征分子谱。本文旨在概述我们对儿童肝肿瘤认识的最新进展。它侧重于儿科肝病学家的观点及其在良性和恶性肝肿瘤多学科管理中的作用。
