Lima Ferreira Manuel, Cachada Baptista Teresa, Alba Diana, Reis Ana
Department of Pediatrics and Neonatology, Unidade Local de Saúde Tâmega e Sousa, Penafiel, PRT.
Cureus. 2025 Jul 16;17(7):e88050. doi: 10.7759/cureus.88050. eCollection 2025 Jul.
Incidental liver lesions (ILLs) in children are increasingly being identified due to the widespread use of imaging techniques. Focal nodular hyperplasia (FNH) is relatively rare in pediatric age, typically diagnosed based on characteristic imaging findings. We report the case of a 16-year-old asymptomatic female patient with persistent isolated elevation of gamma-glutamyl transferase (GGT), identified during routine evaluation. Further imaging, including abdominal ultrasound and magnetic resonance imaging with hepatocyte-specific contrast agent, revealed an ILL consistent with FNH, despite the absence of a classical central scar. The adolescent remained asymptomatic, and conservative follow-up was decided. This case highlights the diagnostic relevance of isolated GGT elevation as a potential indicator of FNH.
由于成像技术的广泛应用,儿童偶然发现的肝脏病变(ILLs)越来越多地被识别出来。局灶性结节性增生(FNH)在儿童期相对少见,通常根据特征性影像学表现进行诊断。我们报告一例16岁无症状女性患者,在常规评估中发现γ-谷氨酰转移酶(GGT)持续单独升高。进一步的影像学检查,包括腹部超声和使用肝细胞特异性造影剂的磁共振成像,显示一个与FNH相符的ILL,尽管没有典型的中央瘢痕。该青少年仍无症状,因此决定进行保守随访。本病例强调了孤立性GGT升高作为FNH潜在指标的诊断意义。