Department of Reproductive Health, School of Medicine - Moi University, Eldoret, Kenya.
PLoS One. 2020 Dec 2;15(12):e0243166. doi: 10.1371/journal.pone.0243166. eCollection 2020.
Abnormal uterine bleeding (AUB) affects 30% of reproductive age women globally. However, there are limited local studies evaluating the management of these women. The diagnostic guideline using structural and functional causes of AUB adopts the PALM-COEIN criteria, namely: Polyp; Adenomyosis; Leiomyoma; Malignancy and Hyperplasia; Coagulopathy; Ovulatory dysfunction; Endometrial; Iatrogenic; and Not yet classified. This study aimed to determine the clinical bleeding patterns, adherence to PALM-COEIN diagnosis guidelines and management of AUB among women in their reproductive age. This was a cross-sectional study among 108 women with AUB aged 18-45 years was conducted at the gynaecology department of Moi Teaching and Referral Hospital in Western Kenya between April 2018 and April 2019. Their sociodemographic and clinical characteristics were collected using interviewer administered structured questionnaire and chart reviews. Adherence to diagnosis recommendations was assessed using PALM COEIN classification. Descriptive and inferential data analysis was conducted at 95% confidence interval. The median age was 30 (IQR: 22, 41) years with prolonged bleeding as the most predominant pattern at 41.7%. Bleeding patterns were significantly associated with age (p = 0.04). Only 16.7% were diagnosed as per the PALM-COEIN criteria with PALM and COEIN accounting for 60% and 40% respectively. Leiomyoma (44.5%) was the common cause of AUB. Laboratory evaluation included: pregnancy tests, full haemogram, hormonal profile and biopsy. Most (79.6%) of the women had abdominopelvic ultrasound done. Medical management was provided for 78.7% of women. Prolonged bleeding was the most common pattern with medical management preferred. There is need for in-hospital algorithms to ensure adherence to PALM-COEIN guidelines.
异常子宫出血 (AUB) 影响全球 30%的育龄妇女。然而,针对这些女性的管理,仅有有限的本地研究进行评估。采用 AUB 的结构性和功能性病因的诊断指南采用 PALM-COEIN 标准,即:息肉;腺肌病;平滑肌瘤;恶性肿瘤和增生;凝血障碍;排卵障碍;子宫内膜;医源性;和未分类。本研究旨在确定育龄妇女的临床出血模式、对 PALM-COEIN 诊断指南的依从性以及 AUB 的管理。这是 2018 年 4 月至 2019 年 4 月在肯尼亚西部莫伊教学和转诊医院妇科进行的一项 108 例年龄在 18-45 岁的 AUB 妇女的横断面研究。使用访谈员管理的结构化问卷和病历回顾收集了他们的社会人口学和临床特征。使用 PALM COEIN 分类评估对诊断建议的依从性。在 95%置信区间进行描述性和推断性数据分析。中位数年龄为 30 岁(IQR:22,41),最主要的出血模式为延长性出血(41.7%)。出血模式与年龄显著相关(p=0.04)。仅 16.7%按 PALM-COEIN 标准诊断,PALM 和 COEIN 分别占 60%和 40%。平滑肌瘤(44.5%)是 AUB 的常见病因。实验室评估包括:妊娠试验、全血细胞计数、激素谱和活检。大多数(79.6%)妇女进行了腹部盆腔超声检查。为 78.7%的妇女提供了药物治疗。延长性出血是最常见的模式,首选药物治疗。需要住院内的算法来确保对 PALM-COEIN 指南的依从性。