Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
PLoS One. 2020 Dec 2;15(12):e0242702. doi: 10.1371/journal.pone.0242702. eCollection 2020.
We examined the data reported in the studies for comparison of osteopontin (OPN) levels in tuberculosis and healthy participants, and to discuss whether OPN could be extended to disease diagnosis, severity assessment and therapeutic effect monitering.
A systematic literature search was conducted in PubMed, EMBASE, Scopus, the Cochrane Library, Web of Science, the China National Knowledge Infrastructure (CNKI) and WanFang databases. The pooled risk estimates were shown in standardized mean difference (SMD) with 95% confidence interval (CI) for OPN levels. The random effect model was used according to the test of heterogeneity among studies. Subgroup analyses and meta-regression models were performed to identify the possible sources of heterogeneity.
17 retrospective studies with 933 tuberculosis participants and 786 healthy controls were finally included in this article. In the primary meta-analysis, higher serum/plasma OPN levels were found in tuberculosis patients (SMD = 2.58, 95%CI = 2.093.08, P<0.001). Besides, pooled results from positive acid-fast bacilli (AFB) staining and imaging-severe tuberculosis group demonstrated higher OPN concentrations (SMD = 0.90, 95%CI = 0.581.21, P<0.001; SMD = 1.11, 95%CI = 0.901.33, P<0.001; respectively), and OPN levels decreased after two months of standard anti-tuberculosis therapy (SMD = 2.10, 95%CI = 1.362.85, P<0.001).
Elevated serum/plasma OPN levels may be associated with an increased risk of tuberculosis, while further well-designed studies are needed. Moreover, OPN could be considered as a potential biomarker for tuberculosis surveillance and severity assessment.
我们对研究中报告的骨桥蛋白（OPN）水平在结核病和健康参与者中的比较数据进行了检查，并讨论了 OPN 是否可以扩展用于疾病诊断、严重程度评估和治疗效果监测。
系统地检索了 PubMed、EMBASE、Scopus、Cochrane 图书馆、Web of Science、中国国家知识基础设施（CNKI）和万方数据库。OPN 水平的汇总风险估计值以标准化均数差（SMD）和 95%置信区间（CI）表示。根据研究间异质性检验，采用随机效应模型。进行亚组分析和荟萃回归模型，以确定可能的异质性来源。
本文最终纳入了 17 项回顾性研究，共 933 例结核病患者和 786 例健康对照者。在主要的荟萃分析中，发现结核病患者的血清/血浆 OPN 水平较高（SMD=2.58，95%CI=2.093.08，P<0.001）。此外，从阳性抗酸杆菌（AFB）染色和影像学严重结核病组的汇总结果表明，OPN 浓度较高（SMD=0.90，95%CI=0.581.21，P<0.001；SMD=1.11，95%CI=0.901.33，P<0.001），并且在接受两个月的标准抗结核治疗后，OPN 水平下降（SMD=2.10，95%CI=1.362.85，P<0.001）。
血清/血浆 OPN 水平升高可能与结核病风险增加有关，需要进一步设计良好的研究。此外，OPN 可以被认为是结核病监测和严重程度评估的潜在生物标志物。
