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东非五岁以下腹泻儿童的锌利用情况及其相关因素:广义线性混合模型。

Zinc utilization and associated factors among under-five children with diarrhea in East Africa: A generalized linear mixed modeling.

机构信息

Department of Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

PLoS One. 2020 Dec 2;15(12):e0243245. doi: 10.1371/journal.pone.0243245. eCollection 2020.

Abstract

INTRODUCTION

Diarrhea is the leading cause of illness and death among under-five children in low and middle income countries. Through the provision of zinc supplements has been shown to reduce the severity and duration of diarrhea, as well as the risk of mortality, the use of zinc for the treatment of diarrhea is still very low in low-income countries. Therefore, this study was conducted to determine the prevalence and associated factors of zinc utilization among under-five children with diarrhea in East Africa.

METHODS

A secondary data analysis of the recent Demographic and Health Surveys (DHS) of East African countries were used to determine the prevalence and associated factors of zinc utilization among under-five children with diarrhea in East Africa. A total weighted samples of 16,875 under-five children with diarrhea were included in the study. A generalized linear mixed model (using Poisson regression with robust error variance) was used. Prevalence Ratios (PR) with their 95% confidence interval (CI) were calculated for those variables included in the final model.

RESULTS

The overall prevalence of zinc utilization among under-five children with diarrhea in this study was 21.54% (95% CI = 20.92-22.16). Of East African countries, Uganda had the highest prevalence of zinc utilization (40.51%) whereas Comoros had the lowest (0.44%). Maternal primary education (Adjusted Prevalence Ratio(aPR) = 1.29, 95% CI: 1.16-1.44), secondary education (aPR = 1.36, 95% CI = 1.19-1.55) and higher education (aPR = 1.91, 95% CI = 1.52-2.40), high community women education (aPR = 1.12, 95% CI = 1.02-1.24), high wealth index (aPR = 1.12, 95% CI = 1.01-1.24), high community media exposure (aPR = 1.17, 95% CI = 1.06-1.29) were associated with a higher prevalence of zinc utilization.

CONCLUSION

The prevalence of zinc utilization among under-five children was found to be low in East Africa. Maternal education, wealth index, community women education, and community media exposure were significantly associated with zinc utilization. Increased mass media exposure, maternal education and wealth index is recommended to improve zinc utilization among under-five children with diarrhea.

摘要

简介

腹泻是中低收入国家五岁以下儿童患病和死亡的主要原因。补锌被证明可以降低腹泻的严重程度和持续时间,以及死亡率,然而在低收入国家,锌的治疗腹泻的使用仍然非常低。因此,本研究旨在确定东非国家五岁以下腹泻儿童使用锌的流行率和相关因素。

方法

利用最近的东非国家人口与健康调查(DHS)的二次数据分析,确定东非国家五岁以下腹泻儿童使用锌的流行率和相关因素。研究共纳入了 16875 名五岁以下腹泻儿童的加权总样本。采用广义线性混合模型(使用泊松回归和稳健误差方差)。对于最终模型中包含的变量,计算了患病率比(PR)及其 95%置信区间(CI)。

结果

本研究中,五岁以下腹泻儿童使用锌的总体流行率为 21.54%(95%CI=20.92-22.16)。在东非国家中,乌干达的锌使用率最高(40.51%),而科摩罗的锌使用率最低(0.44%)。母亲接受小学教育(调整后患病率比[aPR]=1.29,95%CI:1.16-1.44)、中学教育(aPR=1.36,95%CI=1.19-1.55)和高等教育(aPR=1.91,95%CI=1.52-2.40)、高社区妇女教育(aPR=1.12,95%CI=1.02-1.24)、高财富指数(aPR=1.12,95%CI=1.01-1.24)、高社区媒体接触(aPR=1.17,95%CI=1.06-1.29)与较高的锌使用率相关。

结论

研究发现,东非五岁以下儿童使用锌的比例较低。母亲教育、财富指数、社区妇女教育和社区媒体接触与锌的使用显著相关。建议增加大众媒体的宣传,提高母亲教育和财富指数,以改善五岁以下腹泻儿童的锌利用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7f/7710063/ecde35cc1bd1/pone.0243245.g001.jpg

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