两种新型头孢菌素抗菌剂ICI 194008和ICI 193428的体外活性
In vitro activities of ICI 194008 and ICI 193428, two new cephem antimicrobial agents.
作者信息
Allan J D, Eliopoulos G M, Reiszner E, Moellering R C
机构信息
Department of Medicine, New England Deaconess Hospital.
出版信息
Antimicrob Agents Chemother. 1987 Dec;31(12):1997-2001. doi: 10.1128/AAC.31.12.1997.
Abstract
The in vitro activities of two new cephem antibiotics, ICI 193428 and ICI 194008, were compared with those of cefpirome, cefotaxime, ceftazidime, and piperacillin. Essentially all strains of the family Enterobacteriaceae were inhibited by both study drugs at concentrations of less than or equal to 4 micrograms/ml. Both new cephems were comparable to ceftazidime against Pseudomonas aeruginosa (MIC for 90% of strains, 8 micrograms/ml) and were the most active agents tested against Pseudomonas maltophilia (MIC for 90% of strains, 16 micrograms/ml).
摘要
将两种新型头孢烯抗生素ICI 193428和ICI 194008的体外活性与头孢匹罗、头孢噻肟、头孢他啶和哌拉西林进行了比较。本质上，所有肠杆菌科菌株在浓度小于或等于4微克/毫升时均被这两种研究药物抑制。两种新型头孢菌素对铜绿假单胞菌的活性与头孢他啶相当（90%菌株的MIC为8微克/毫升），并且是测试的对嗜麦芽窄食单胞菌活性最强的药物（90%菌株的MIC为16微克/毫升）。
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