Szeliga Monika
Mossakowski Medical Research Centre, Department of Neurotoxicology, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Antioxidants (Basel). 2020 Nov 30;9(12):1203. doi: 10.3390/antiox9121203.
Substantial evidence indicates that oxidative/nitrosative stress contributes to the neurodegenerative diseases. Peroxiredoxins (PRDXs) are one of the enzymatic antioxidant mechanisms neutralizing reactive oxygen/nitrogen species. Since mammalian PRDXs were identified 30 years ago, their significance was long overshadowed by the other well-studied ROS/RNS defense systems. An increasing number of studies suggests that these enzymes may be involved in the neurodegenerative process. This article reviews the current knowledge on the expression and putative roles of PRDXs in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies, multiple sclerosis, amyotrophic lateral sclerosis and Huntington's disease.
大量证据表明，氧化/亚硝化应激与神经退行性疾病有关。过氧化物酶（PRDXs）是中和活性氧/氮物质的酶促抗氧化机制之一。自30年前发现哺乳动物PRDXs以来，它们的重要性长期被其他研究充分的ROS/RNS防御系统所掩盖。越来越多的研究表明，这些酶可能参与神经退行性过程。本文综述了目前关于PRDXs在阿尔茨海默病、帕金森病、路易体痴呆、多发性硬化症、肌萎缩侧索硬化症和亨廷顿舞蹈病等神经退行性疾病中的表达及假定作用的知识。
