Rahman Sami Ur, Bilal Salma, Ul Haq Ali Shah Anwar
National Centre of Excellence in Physical Chemistry, University of Peshawar, Peshawar 25120, Pakistan.
Institute of Chemical Science, University of Peshawar, Peshawar 25120, Pakistan.
Polymers (Basel). 2020 Nov 30;12(12):2870. doi: 10.3390/polym12122870.
Electroconductive polymeric patches are being developed in the hope to interface with the electroresponsive tissues. For these constructs, conjugated polymers are considered as conductive components for their electroactive nature. Conversely, the clinical applications of these conductive polymeric patches are limited due to their short operational time-a decrease in their electroactivity occurs with the passage of time. This paper reports on the polymerization of aniline on prefabricated chitosan films on microscopic glass slides in the presence of sodium phytate. The strong chelation among sodium phytate, aniline and chitosan led to the formation of electoconductive polymeric patch. We assume that immobilization of sodium phytate in the polymeric patch helps to prevent electric deterioration, extend its electronic stability and reduce sheet resistance. The patch oxidized after three weeks (21 days) of incubation in phosphate buffer (pH 7.4 as physiological medium). This feasible fabrication technique set the foundation to design electronically stable, conjugated polymer-based patches, by providing a robust system of conduction that could be used with electroactive tissues such as cardiac muscles at the interface.
导电聚合物贴片正在被研发，以期与电响应组织实现接口连接。对于这些构建体而言，共轭聚合物因其电活性本质而被视为导电组件。相反，这些导电聚合物贴片的临床应用受到限制，因为它们的操作时间较短——随着时间的推移，其电活性会降低。本文报道了在植酸钠存在的情况下，苯胺在微观载玻片上预制的壳聚糖薄膜上的聚合反应。植酸钠、苯胺和壳聚糖之间的强螯合作用导致了导电聚合物贴片的形成。我们认为，植酸钠固定在聚合物贴片中有助于防止电性能恶化，延长其电子稳定性并降低薄层电阻。该贴片在磷酸盐缓冲液（pH 7.4作为生理介质）中孵育三周（21天）后被氧化。这种可行的制造技术通过提供一个强大的传导系统，为设计电子稳定的、基于共轭聚合物的贴片奠定了基础，该传导系统可用于如心肌等电活性组织的界面处。
