Gleason J A, Winer W, Turner J L
Stormont-Vail Hospital, Topeka, Kansas.
Clin Ther. 1987;9(6):585-93.
Meclofenamate sodium, a nonsteroidal anti-inflammatory drug with proven analgesic effects, was compared at two dose levels (200 mg and 100 mg) with codeine (60 mg) and placebo in a double-blind, randomized study of 327 women experiencing episiotomy pain after normal delivery. Meclofenamate sodium at either dose was significantly better than codeine or placebo in reducing pain intensity and increasing pain relief, and it had a longer duration of action. Adverse effects were minimal, and their frequency did not differ significantly among treatment groups. Meclofenamate sodium appears to be as safe as and more effective than codeine for the management of episiotomy pain.
甲氯芬那酸钠是一种具有确切镇痛作用的非甾体抗炎药，在一项针对327名正常分娩后发生会阴切开术疼痛的女性的双盲、随机研究中，将其两个剂量水平（200毫克和100毫克）与可待因（60毫克）和安慰剂进行了比较。两种剂量的甲氯芬那酸钠在减轻疼痛强度和增强疼痛缓解方面均显著优于可待因或安慰剂，且作用持续时间更长。不良反应轻微，各治疗组之间其发生率无显著差异。对于会阴切开术疼痛的处理，甲氯芬那酸钠似乎与可待因一样安全且更有效。
