Hebertson R M, Storey N, Turner J L
Pharmacotherapy. 1986 Sep-Oct;6(5):205-10. doi: 10.1002/j.1875-9114.1986.tb03478.x.
Meclofenamate sodium was compared, double-blind, with codeine and placebo for the treatment of acute episiotomy pain. One hundred sixty-eight women with moderate or severe episiotomy pain after normal delivery were assigned randomly to one of four treatment groups: one received meclofenamate sodium 200 mg at dose 1 and 100 mg at doses 2 and 3; one received meclofenamate sodium 100 mg at dose 1 and 50 mg at doses 2 and 3; one received codeine 60 mg at all three doses; and one received placebo at all three doses. Efficacy measurements were evaluated periodically for 6 hours after medication. After the first administration, both doses of meclofenamate sodium were significantly superior to placebo and to codeine from 2-6 hours in pain intensity difference and pain relief. For second and third doses, data were available for too few patients to allow valid analysis and interpretation. Adverse effects occurred in 4 patients in each meclofenamate sodium group, and in 8 in the codeine group and in 6 in the placebo group. The study indicates that single 100- and 200-mg doses of meclofenamate sodium are as safe as, and significantly more effective than, codeine 60 mg or placebo for episiotomy pain.
对甲氯芬那酸钠、可待因和安慰剂治疗急性会阴切开术后疼痛进行了双盲比较。168例正常分娩后有中度或重度会阴切开术疼痛的妇女被随机分配到四个治疗组之一：一组在第1剂时接受200mg甲氯芬那酸钠，在第2剂和第3剂时接受100mg；一组在第1剂时接受100mg甲氯芬那酸钠，在第2剂和第3剂时接受50mg；一组在所有三剂时均接受60mg可待因；一组在所有三剂时均接受安慰剂。用药后6小时定期评估疗效指标。首次给药后，两种剂量的甲氯芬那酸钠在2至6小时的疼痛强度差异和疼痛缓解方面均显著优于安慰剂和可待因。对于第2剂和第3剂，由于患者数量太少，无法进行有效的分析和解释。甲氯芬那酸钠组各有4例出现不良反应，可待因组有8例，安慰剂组有6例。该研究表明，单次100mg和200mg剂量的甲氯芬那酸钠在治疗会阴切开术疼痛方面与60mg可待因或安慰剂一样安全，且显著更有效。
