转化再生医学蓝图。
A blueprint for translational regenerative medicine.
作者信息
Armstrong James P K, Keane Timothy J, Roques Anne C, Patrick P Stephen, Mooney Claire M, Kuan Wei-Li, Pisupati Venkat, Oreffo Richard O C, Stuckey Daniel J, Watt Fiona M, Forbes Stuart J, Barker Roger A, Stevens Molly M
机构信息
Department of Materials, Imperial College London, London SW7 2AZ, UK.
Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
出版信息
Sci Transl Med. 2020 Dec 2;12(572). doi: 10.1126/scitranslmed.aaz2253.
The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called "valley of death." Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.
在过去几十年里，再生医学领域开展了大量概念验证研究。然而，临床应用之路充满了技术和转化障碍，这些障碍常常使有前景的学术解决方案陷入所谓的“死亡谷”。在此，我们提出了一份转化性再生医学的蓝图。我们提供了有助于指导细胞和材料选择的原则，介绍了关键的体内成像模式，并认为在整个设计和开发过程中都应考虑宿主免疫反应。最后，我们提出了一条途径，以应对转化性再生医学中通常复杂的监管和制造局面。
Zotero 插件