新兴的组织工程技术：从基因编辑到个性化医疗。
Emerging Technologies for Tissue Engineering: From Gene Editing to Personalized Medicine.
机构信息
Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, United Kingdom.
出版信息
Tissue Eng Part A. 2019 May;25(9-10):688-692. doi: 10.1089/ten.TEA.2019.0026.
Abstract
History has shown us how tissue engineering can be advanced by embracing technological innovation. In this perspective, we highlight some of the most promising emerging technologies and discuss how they can be integrated into existing tissue engineering protocols. The proposed technologies offer the opportunity to reshape how we currently design, engineer, and characterize tissue grafts for improved regeneration.
摘要
历史告诉我们，通过拥抱技术创新，组织工程学可以取得进步。从这个角度出发，我们重点介绍了一些最有前途的新兴技术，并讨论了它们如何融入现有的组织工程学方案中。这些新技术为我们当前如何设计、构建和表征组织移植物以实现更好的再生提供了机会。
相似文献
1
Emerging Technologies for Tissue Engineering: From Gene Editing to Personalized Medicine.新兴的组织工程技术：从基因编辑到个性化医疗。
Tissue Eng Part A. 2019 May;25(9-10):688-692. doi: 10.1089/ten.TEA.2019.0026.
2
The Third Era of Tissue Engineering: Reversing the Innovation Drivers.组织工程的第三时代：颠覆创新驱动力。
Tissue Eng Part A. 2019 Jun;25(11-12):821-826. doi: 10.1089/ten.TEA.2019.0064. Epub 2019 May 2.
3
Epigenome engineering: new technologies for precision medicine.表观基因组工程：精准医学的新技术。
Nucleic Acids Res. 2020 Dec 16;48(22):12453-12482. doi: 10.1093/nar/gkaa1000.
4
CRISPR in 3D: Innovations in Disease Modelling and Personalized Medicine.
Biotechniques. 2024 Oct;76(10):473-478. doi: 10.1080/07366205.2024.2418748. Epub 2024 Nov 28.
5
Osteosarcoma, personalized medicine, and tissue engineering; an overview of overlapping fields of research.骨肉瘤、个性化医疗和组织工程；研究重叠领域概述。
Cancer Treat Res Commun. 2021;27:100324. doi: 10.1016/j.ctarc.2021.100324. Epub 2021 Jan 27.
6
Genome Editing and Induced Pluripotent Stem Cell Technologies for Personalized Study of Cardiovascular Diseases.基因组编辑和诱导多能干细胞技术在心血管疾病个体化研究中的应用。
Curr Cardiol Rep. 2018 Apr 17;20(6):38. doi: 10.1007/s11886-018-0984-9.
7
Mammalian synthetic biology in the age of genome editing and personalized medicine.基因组编辑与个性化医疗时代的哺乳动物合成生物学
Curr Opin Chem Biol. 2017 Oct;40:57-64. doi: 10.1016/j.cbpa.2017.06.003. Epub 2017 Jun 16.
8
Engineering hydrogels for personalized disease modeling and regenerative medicine.用于个性化疾病建模和再生医学的水凝胶工程。
Acta Biomater. 2021 Sep 15;132:4-22. doi: 10.1016/j.actbio.2021.04.020. Epub 2021 Apr 18.
9
Emerging Strategies in Cartilage Repair and Joint Preservation.软骨修复与关节保留的新兴策略
Medicina (Kaunas). 2024 Dec 27;61(1):24. doi: 10.3390/medicina61010024.
10
Emulating Human Tissues and Organs: A Bioprinting Perspective Toward Personalized Medicine.模拟人体组织和器官：个性化医疗的生物打印视角。
Chem Rev. 2020 Oct 14;120(19):11128-11174. doi: 10.1021/acs.chemrev.0c00342. Epub 2020 Sep 16.
引用本文的文献
1
Gingival fibroblast suppress the osteogenesis process mediated by bone substitute materials via WNT/β-catenin signaling pathway and .牙龈成纤维细胞通过WNT/β-连环蛋白信号通路抑制骨替代材料介导的骨生成过程。
Front Bioeng Biotechnol. 2025 Feb 10;13:1521134. doi: 10.3389/fbioe.2025.1521134. eCollection 2025.
2
Recent advances in artificial intelligent strategies for tissue engineering and regenerative medicine.人工智能策略在组织工程和再生医学中的最新进展。
Skin Res Technol. 2024 Sep;30(9):e70016. doi: 10.1111/srt.70016.
3
The challenges and prospects of smooth muscle tissue engineering.平滑肌组织工程面临的挑战与展望。
Regen Med. 2024 Mar;19(3):135-143. doi: 10.2217/rme-2023-0230. Epub 2024 Mar 5.
4
Biomaterials-mediated CRISPR/Cas9 delivery: recent challenges and opportunities in gene therapy.生物材料介导的CRISPR/Cas9递送：基因治疗中的近期挑战与机遇
Front Chem. 2023 Sep 28;11:1259435. doi: 10.3389/fchem.2023.1259435. eCollection 2023.
5
Mass Spectrometry Imaging Reveals Early Metabolic Priming of Cell Lineage in Differentiating Human-Induced Pluripotent Stem Cells.质谱成像揭示了人诱导多能干细胞分化过程中细胞谱系的早期代谢启动。
Anal Chem. 2023 Mar 21;95(11):4880-4888. doi: 10.1021/acs.analchem.2c04416. Epub 2023 Mar 10.
6
Theranostic biomaterials for tissue engineering.用于组织工程的诊疗一体化生物材料。
Curr Opin Biomed Eng. 2021 Sep;19. doi: 10.1016/j.cobme.2021.100299. Epub 2021 May 26.
7
The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells.黄酮类化合物在间充质干细胞成骨分化中的作用
Front Pharmacol. 2022 Apr 6;13:849513. doi: 10.3389/fphar.2022.849513. eCollection 2022.
8
Natural Scaffolds Used for Liver Regeneration: A Narrative Update.用于肝脏再生的天然支架：叙述性更新。
Stem Cell Rev Rep. 2022 Oct;18(7):2262-2278. doi: 10.1007/s12015-022-10362-8. Epub 2022 Mar 23.
9
Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications.用于心脏、神经和骨组织工程应用的天然水凝胶的生物制造。
Bioact Mater. 2021 Apr 15;6(11):3904-3923. doi: 10.1016/j.bioactmat.2021.03.040. eCollection 2021 Nov.
10
Emerging strategies in reprogramming and enhancing the fate of mesenchymal stem cells for bone and cartilage tissue engineering.新兴策略在重编程和增强间充质干细胞的命运用于骨和软骨组织工程。
J Control Release. 2021 Feb 10;330:565-574. doi: 10.1016/j.jconrel.2020.12.055. Epub 2020 Dec 31.
本文引用的文献
1
Fractal-like hierarchical organization of bone begins at the nanoscale.骨的类分形层次结构组织始于纳米尺度。
Science. 2018 May 4;360(6388). doi: 10.1126/science.aao2189.
2
Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis.用于多发性硬化症再髓鞘化生物分子分析的相关异谱脂质组学
ACS Cent Sci. 2018 Jan 24;4(1):39-51. doi: 10.1021/acscentsci.7b00367. Epub 2017 Dec 27.
3
Programmable Hydrogels for Cell Encapsulation and Neo-Tissue Growth to Enable Personalized Tissue Engineering.可编程水凝胶用于细胞封装和新组织生长以实现个性化组织工程。
Adv Healthc Mater. 2018 Jan;7(1). doi: 10.1002/adhm.201700605. Epub 2017 Oct 4.
4
The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation.Wnt5a 受体，受体酪氨酸激酶样孤儿受体 2，是一种具有增强的软骨分化能力的人骨髓间充质干细胞的预测性细胞表面标志物。
Stem Cells. 2017 Nov;35(11):2280-2291. doi: 10.1002/stem.2691. Epub 2017 Aug 30.
5
High-Resolution Patterned Cellular Constructs by Droplet-Based 3D Printing.基于液滴的 3D 打印的高分辨率图案化细胞构建体。
Sci Rep. 2017 Aug 1;7(1):7004. doi: 10.1038/s41598-017-06358-x.
6
Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy.使用漫射光纤拉曼光谱对活细胞工程软骨生长进行在线定量监测。
Biomaterials. 2017 Sep;140:128-137. doi: 10.1016/j.biomaterials.2017.06.015. Epub 2017 Jun 14.
7
Big-Data-Driven Stem Cell Science and Tissue Engineering: Vision and Unique Opportunities.大数据驱动的干细胞科学与组织工程：愿景与独特机遇。
Cell Stem Cell. 2017 Feb 2;20(2):157-160. doi: 10.1016/j.stem.2017.01.006.
8
Raman Spectroscopy Reveals New Insights into the Zonal Organization of Native and Tissue-Engineered Articular Cartilage.拉曼光谱揭示了对天然和组织工程化关节软骨区域组织的新见解。
ACS Cent Sci. 2016 Dec 28;2(12):885-895. doi: 10.1021/acscentsci.6b00222. Epub 2016 Nov 16.
9
Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.基于CRISPR/Cas9的转录激活因子对内源基因座进行靶向表观遗传重塑可直接将成纤维细胞转化为神经元细胞。
Cell Stem Cell. 2016 Sep 1;19(3):406-14. doi: 10.1016/j.stem.2016.07.001. Epub 2016 Aug 11.
10
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.空间转录组学在组织切片中基因表达的可视化和分析。
Science. 2016 Jul 1;353(6294):78-82. doi: 10.1126/science.aaf2403.
Zotero 插件