肠道微生物群和免疫系统在自闭症发展中的作用
The Role of the Gut Microbiota and the Immune System in the Development of Autism.
作者信息
Lungba Rayan M, Khan Seyad Zulficar Ali, Ajibawo-Aganbi Uvie, Perez Bastidas Maria V, Veliginti Swathi, Saleem Sania, Cancarevic Ivan
机构信息
Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
出版信息
Cureus. 2020 Oct 28;12(10):e11226. doi: 10.7759/cureus.11226.
Autism spectrum disorders (ASDs) are neurodevelopmental disorders that present with social skills and communication challenges, restricted interest, and repetitive behavior. The specific cause of autism is not well understood yet. However, numerous studies indicated that environmental and genetic factors, dysregulated immune response, and alterations to the balance and content of the gut microbiota are implemented in the development of autism. Many non-pharmacological interventions are nominated to manage autism, including family support services and psychoeducational methods. Moreover, different pharmacological therapy modalities are recommended for children with ASD. Learning more about the brain, immune system, and gut connections could assist in early diagnosis and treatment of this devastating neurodevelopmental disorders as an early intervention in ASD could improve a child's overall development. We gathered data from relevant previously published articles on PubMed to evaluate the role of the gut microbiota and the immune system on the development of autism..
自闭症谱系障碍（ASDs）是神经发育障碍，表现为社交技能和沟通方面的挑战、兴趣受限以及重复行为。自闭症的确切病因尚未完全明确。然而，大量研究表明，环境和遗传因素、免疫反应失调以及肠道微生物群的平衡和组成改变与自闭症的发展有关。许多非药物干预措施被推荐用于管理自闭症，包括家庭支持服务和心理教育方法。此外，针对自闭症儿童推荐了不同的药物治疗方式。更多地了解大脑、免疫系统和肠道之间的联系，有助于早期诊断和治疗这种严重的神经发育障碍，因为对自闭症的早期干预可以改善儿童的整体发育。我们从PubMed上先前发表的相关文章中收集数据，以评估肠道微生物群和免疫系统在自闭症发展中的作用。
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