Department of Haematolgy and Oncology, Center of Transfusion Medicine, Pescara General Hospital, Pescara, Italy.
Department of Clinical Epidemiology, Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy.
Transfus Med. 2021 Jun;31(3):160-166. doi: 10.1111/tme.12742. Epub 2020 Dec 2.
We evaluated how the Severe Acute Respiratory disease from Coronavirus 2 (SARS-CoV-2) epidemic impacted transfusion services, transfusion support required by Covid-19 patients and their clinical outcome.
In Italy, the first confirmed case of SARS-CoV-2 infection was registered on 21 February 2020. As of 20 April, about 250 000 cases were registered, 1143 of which were in the province of Pescara.
We compared transfusion services provided by the blood centre of Pescara between 1 March and 20 April 2019 and between 1 March and 20 April 2020. We assessed the number and type of blood components donated, those transfused in the various hospital departments and those transfused to Covid-19 patients.
Compared to 2019, we documented a decrease of 32% in the number of donations. The number of transfusions increased by 139% in the infectious diseases department (IDD), dedicated to Covid-19 patients, and by 76% in the intensive care unit (ICU), whereas it markedly decreased in the other departments. Of 299 patients with Covid-19, 60 were transfused (20.1%). Transfused patients in the ICU were significantly younger than those in IDD and had a lower number of lymphocytes, lower post-transfusion increment of haemoglobin levels and higher D-dimer and C reactive protein values. Mortality rate was 60.7% among transfused patients in the ICU and 39.0% among those in the IDD (p = 0.02).
The Covid-19 epidemic had a profound impact on transfusion activities. The important blood demand for Covid-19 patients was satisfied because of the reduction in activities in other hospital wards. Covid-19-positive transfused patients showed a very poor prognosis.
评估 2019 年冠状病毒病（COVID-19）大流行对输血服务、COVID-19 患者所需输血支持及其临床结局的影响。
在意大利，首例 2019 年冠状病毒病（SARS-CoV-2）感染确诊病例于 2020 年 2 月 21 日报告。截至 2020 年 4 月 20 日，已报告约 25 万例病例，其中 1143 例在佩斯卡拉省。
我们比较了佩斯卡拉血液中心在 2019 年 3 月 1 日至 2020 年 4 月 20 日期间和 2020 年 3 月 1 日至 2020 年 4 月 20 日期间提供的输血服务。评估了献血数量和类型、各医院科室输注的血液成分以及输注给 COVID-19 患者的血液成分。
与 2019 年相比，我们记录的献血数量减少了 32%。传染病科（ID）的输注量增加了 139%（专门用于 COVID-19 患者），重症监护病房（ICU）的输注量增加了 76%，而其他科室的输注量则明显减少。在 299 例 COVID-19 患者中，有 60 例接受了输血（20.1%）。ICU 中接受输血的患者明显比 ID 中接受输血的患者年轻，淋巴细胞数量更少，输血后血红蛋白水平升高幅度更小，D-二聚体和 C 反应蛋白值更高。ICU 中接受输血的患者死亡率为 60.7%，ID 中接受输血的患者死亡率为 39.0%（p=0.02）。
COVID-19 大流行对输血活动产生了深远影响。由于其他病房活动减少，COVID-19 患者对血液的大量需求得到了满足。COVID-19 阳性输血患者预后极差。
