Health and Lifestyle Research Unit, Queen Mary University of London, 2 Stayner's Road, London, E14AH, UK.
Psychopharmacology (Berl). 2021 Mar;238(3):825-831. doi: 10.1007/s00213-020-05734-2. Epub 2020 Dec 3.
The degree to which the EU version of Juul with 20 mg/ml nicotine (Juul EU) delivers nicotine to users is likely to determine its treatment potential.
To compare the pharmacokinetic profile and user ratings of Juul EU, Juul US (59 mg/ml nicotine), cigarettes and other e-cigarette (EC) products.
In a within-subjects crossover design, 18 vapers used, at separate sessions, their own brand cigarette (OBC), Juul US and Juul EU for 5 min ad libitum, after overnight abstinence. Seven of the participants also tested eight other EC previously. Blood samples were taken at baseline and 2, 4, 6, 8, 10 and 30 min after initiating product use. Products were rated on a range of characteristics.
Juul EU delivered less nicotine than OBC (t(13) = -4.64 p < .001) and than Juul US (t(13) = -6.40, p < .001): AUC 77.3, 324.8 and 355.9, respectively. Maximum nicotine concentration (C) was also much lower for Juul EU than Juul US (z = -3.59, p < .001): C 3.8 ng/ml vs 21.1 ng/ml, respectively. Juul EU was perceived to relieve urges to smoke less than Juul US (z = -2.29, p = .022) and to provide less nicotine (z = -2.57. p = 0.010). Juul EU delivered less nicotine than refillable EC (C: t(6) = 3.02, p = 0.023; AUC: z = -2.20, p = 0.028) and also less than cig-a-like EC, though the difference did not reach significance (C: t(6) = 2.49, p = 0.047; AUC: z = -1.99, p = 0.046). Subjective ratings of Juul EU and other EC products were similar.
Juul EU delivers much less nicotine to users than Juul US, and also less than refillable EC products. It may thus have more limited potential to help smokers quit.
欧盟版 Juul 含有 20 毫克/毫升尼古丁（Juul EU）向使用者输送尼古丁的程度可能决定其治疗潜力。
比较 Juul EU、Juul US（59 毫克/毫升尼古丁）、香烟和其他电子烟（EC）产品的药代动力学特征和使用者评价。
在一项自身交叉设计中，18 名电子烟使用者在一夜戒断后，分别在单独的时段内使用自己的品牌香烟（OBC）、Juul US 和 Juul EU 进行 5 分钟随意吸食。其中 7 名参与者还测试了其他 8 种 EC 产品。在开始使用产品后 2、4、6、8、10 和 30 分钟时采集血样。产品的特性按照一系列特征进行评价。
与 OBC（t(13)=-4.64，p<.001）和 Juul US（t(13)=-6.40，p<.001）相比，Juul EU 输送的尼古丁较少：AUC 分别为 77.3、324.8 和 355.9。与 Juul US 相比，Juul EU 的最大尼古丁浓度（C）也低得多（z=-3.59，p<.001）：C 分别为 3.8ng/ml 和 21.1ng/ml。与 Juul US 相比，参与者认为 Juul EU 缓解吸烟冲动的效果较差（z=-2.29，p=.022），提供的尼古丁较少（z=-2.57，p=.010）。与可再填充 EC（C：t(6)=3.02，p=0.023；AUC：z=-2.20，p=0.028）相比，Juul EU 输送的尼古丁较少，与类似雪茄的 EC 产品相比，虽然差异没有达到显著水平（C：t(6)=2.49，p=0.047；AUC：z=-1.99，p=0.046）。对 Juul EU 和其他 EC 产品的主观评价相似。
与 Juul US 相比，Juul EU 向使用者输送的尼古丁要少得多，也比可再填充 EC 产品少。因此，它可能对帮助吸烟者戒烟的潜力有限。
