Health and Lifestyle Research Unit, Queen Mary University of London, 2 Stayner's Road, London, E1 4AH, UK.
Psychopharmacology (Berl). 2018 Apr;235(4):1083-1092. doi: 10.1007/s00213-017-4826-z. Epub 2018 Jan 6.
Little is known about features of e-cigarettes (EC) that facilitate or hinder the switch from smoking to vaping. We tested eight brands of EC to determine how nicotine delivery and other product characteristics influence user's initial reactions.
Fifteen vapers tested each product after overnight abstinence from both smoking and vaping. At each session, participant's vaped ad lib for 5 min. Blood samples were taken at baseline and at 2, 4, 6, 8, 10 and 30 min after starting vaping. Participants rated the products on a range of characteristics. The products tested included six 'cig-a-like' and two refillable products, one with variable voltage. We also tested participants' own EC.
All products significantly reduced urges to smoke. Refillable products delivered more nicotine and received generally superior ratings in terms of craving relief, subjective nicotine delivery, throat hit and vapour production but in overall ratings, they were joined by a cig-a-like, Blu. Participants puffed more on low nicotine delivery products. Participants' estimates of nicotine delivery from different EC were closely linked to 'throat hit'. Nicotine delivery was less important in the initial product ratings than draw resistance, mouthpiece comfort and effects on reducing urge to smoke.
All EC products reduced urges to smoke. Refillable products received generally more favourable ratings than 'cig-a-likes' with similar nicotine content. Perception of nicotine delivery was guided by throat sensations. Lower nicotine delivery was associated with more frequent puffing. The first impressions of EC products are guided less by nicotine delivery than by sensory signals.
人们对电子烟(EC)促进或阻碍吸烟者转向电子烟的特点知之甚少。我们测试了 8 个品牌的 EC,以确定尼古丁输送和其他产品特性如何影响用户的初始反应。
15 名电子烟使用者在一夜不吸烟和不吸电子烟后,对每种产品进行测试。在每一次试验中,参与者自由吸食 5 分钟。在开始吸食电子烟后的 2、4、6、8、10 和 30 分钟时采集血样。参与者对产品的一系列特性进行了评分。测试的产品包括 6 种“类似香烟”和 2 种可再填充产品,其中一种具有可变电压。我们还测试了参与者自己的 EC。
所有产品均显著降低了吸烟的欲望。可再填充产品输送了更多的尼古丁,在缓解渴望、主观尼古丁输送、喉咙刺激和蒸汽产生方面得到了普遍较高的评价,但在总体评价中,与“类似香烟”产品 Blu 并列。参与者在吸食低尼古丁输送产品时吸得更多。不同 EC 产品的尼古丁输送估计与“喉咙刺激”密切相关。在初始产品评价中,尼古丁输送不如抽吸阻力、吸嘴舒适度和减少吸烟欲望的效果重要。
所有 EC 产品均降低了吸烟的欲望。可再填充产品比具有相似尼古丁含量的“类似香烟”产品获得了更普遍的好评。对尼古丁输送的感知受喉咙感觉的影响。较低的尼古丁输送与更频繁的吸食有关。对 EC 产品的第一印象受感觉信号的影响大于尼古丁输送。