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铁在行动:通过 NCOA4 动员肝脏铁。

Iron on the move: mobilizing liver iron via NCOA4.

机构信息

National Institute of Diabetes and Digestive and Kidney Diseases.

出版信息

Blood. 2020 Dec 3;136(23):2604-2605. doi: 10.1182/blood.2020007971.

DOI:10.1182/blood.2020007971
PMID:33270853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7735157/
Abstract

In this issue of , Li et al have demonstrated that NCOA4, the autophagic receptor for ferritin, is necessary for the mobilization of liver iron stores during stress erythropoiesis in mice.

摘要

本期 杂志中,李等人表明,铁蛋白的自噬受体 NCOA4 在应激性红细胞生成过程中肝脏铁储存的动员中是必需的。

相似文献

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Iron on the move: mobilizing liver iron via NCOA4.铁在行动:通过 NCOA4 动员肝脏铁。
Blood. 2020 Dec 3;136(23):2604-2605. doi: 10.1182/blood.2020007971.
2
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.通过NCOA4的铁蛋白自噬是红细胞生成所必需的,并受铁依赖性HERC2介导的蛋白水解调节。
Elife. 2015 Oct 5;4:e10308. doi: 10.7554/eLife.10308.
3
NCOA4 Deficiency Impairs Systemic Iron Homeostasis.NCOA4 缺乏会损害全身铁稳态。
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4
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NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms.NCOA4 通过细胞自主和非自主机制维持小鼠的红细胞生成。
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Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.铁蛋白铁调节因子PCBP1和NCOA4在发育中的红细胞中对细胞铁状态作出反应。
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Nuclear receptor coactivator 4-mediated ferritinophagy drives proliferation of dental pulp stem cells in hypoxia.核受体辅激活因子 4 介导的铁蛋白自噬促进低氧环境下牙髓干细胞的增殖。
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Thermodynamic and Kinetic Studies of the Interaction of Nuclear Receptor Coactivator-4 (NCOA4) with Human Ferritin.核受体共激活因子-4(NCOA4)与人铁蛋白相互作用的热力学和动力学研究。
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本文引用的文献

1
NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss.NCOA4 受 HIF 调控,介导失血性小鼠肝铁动员。
Blood. 2020 Dec 3;136(23):2691-2702. doi: 10.1182/blood.2020006321.
2
A PCBP1-BolA2 chaperone complex delivers iron for cytosolic [2Fe-2S] cluster assembly.PCBP1-BolA2 伴侣复合物为细胞溶质 [2Fe-2S] 簇组装提供铁。
Nat Chem Biol. 2019 Sep;15(9):872-881. doi: 10.1038/s41589-019-0330-6. Epub 2019 Aug 12.
3
Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.铁蛋白铁调节因子PCBP1和NCOA4在发育中的红细胞中对细胞铁状态作出反应。
Blood Cells Mol Dis. 2018 Mar;69:75-81. doi: 10.1016/j.bcmd.2017.09.009. Epub 2017 Sep 28.
4
Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways.哺乳动物铁硫蛋白在铁稳态调节和关键代谢途径中的生物合成与功能
J Biol Chem. 2017 Aug 4;292(31):12744-12753. doi: 10.1074/jbc.R117.789537. Epub 2017 Jun 14.
5
PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis.PCBP1和NCOA4调节红系铁储存和血红素生物合成。
J Clin Invest. 2017 May 1;127(5):1786-1797. doi: 10.1172/JCI90519. Epub 2017 Apr 4.
6
Ferritin, cellular iron storage and regulation.铁蛋白、细胞铁储存与调节
IUBMB Life. 2017 Jun;69(6):414-422. doi: 10.1002/iub.1621. Epub 2017 Mar 27.
7
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.通过NCOA4的铁蛋白自噬是红细胞生成所必需的,并受铁依赖性HERC2介导的蛋白水解调节。
Elife. 2015 Oct 5;4:e10308. doi: 10.7554/eLife.10308.
8
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.选择性 VPS34 抑制剂阻断自噬作用,并揭示 NCOA4 在体内铁蛋白降解和铁平衡中的作用。
Nat Cell Biol. 2014 Nov;16(11):1069-79. doi: 10.1038/ncb3053. Epub 2014 Oct 19.
9
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.定量蛋白质组学鉴定 NCOA4 为介导铁蛋白自噬的货物受体。
Nature. 2014 May 1;509(7498):105-9. doi: 10.1038/nature13148. Epub 2014 Mar 30.
10
A cytosolic iron chaperone that delivers iron to ferritin.一种将铁传递给铁蛋白的胞质铁伴侣蛋白。
Science. 2008 May 30;320(5880):1207-10. doi: 10.1126/science.1157643.