肠道微生物群与鸡马立克氏病病毒感染的保护有关。
Gut microbiota is associated with protection against Marek's disease virus infection in chickens.
机构信息
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada; Department of Pathology and Molecular Medicine & McMaster Immunology Research Centre, M.G DeGroote School of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.
出版信息
Virology. 2021 Jan 15;553:122-130. doi: 10.1016/j.virol.2020.10.011. Epub 2020 Nov 20.
Marek's Disease Virus (MDV) infects chickens via respiratory route and causes lymphomas in internal organs including gastrointestinal tract. MDV infection causes a shift in the gut microbiota composition. However, interactions between the gut microbiota and immune responses against MDV infection are not well understood. Therefore, the current study was performed to understand the effect of the gut microbiota on Marek's disease (MD) pathogenesis. The findings showed that depletion of gut microbiota increased the severity of MD in infected chickens. In addition, an increase in the transcription of interferon (IFN)-α, IFN-β and IFN-γ in the bursa of Fabricius at 4 days post-infection (dpi) was observed in the gut microbiota depleted chickens. The observations in this study shed more light on the association between the gut microbiota and MDV infection in chickens. More research is needed to explore the mechanisms of involvement of the gut microbiota in immunity against MD in chickens.
马立克氏病病毒（MDV）通过呼吸道感染鸡，并导致胃肠道等内脏器官的淋巴瘤。MDV 感染会导致肠道微生物群落组成发生变化。然而，肠道微生物群与针对 MDV 感染的免疫反应之间的相互作用尚不清楚。因此，目前的研究旨在了解肠道微生物群对马立克氏病（MD）发病机制的影响。研究结果表明，肠道微生物群的耗竭会增加感染鸡 MD 的严重程度。此外，在肠道微生物群耗竭的鸡中，观察到法氏囊在感染后 4 天（dpi）时干扰素（IFN）-α、IFN-β 和 IFN-γ的转录增加。本研究中的观察结果进一步阐明了肠道微生物群与鸡 MDV 感染之间的关联。需要进一步研究来探索肠道微生物群在鸡对 MD 的免疫中的参与机制。
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