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25-羟基胆固醇在脂质代谢、抗病毒过程、炎症反应及细胞存活中的多重作用

Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival.

作者信息

Cao Qin, Liu Zhongzhong, Xiong Yan, Zhong Zibiao, Ye Qifa

机构信息

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Engineering Research Center of Natural Polymer-based Medical Materials in Hubei Province, Wuhan, China 430071.

The Third Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, China 410013.

出版信息

Oxid Med Cell Longev. 2020 Nov 19;2020:8893305. doi: 10.1155/2020/8893305. eCollection 2020.

DOI:10.1155/2020/8893305
PMID:33274010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7695496/
Abstract

As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades. Among which, the role of 25-hydroxycholesterol (25-HC) in cholesterol and bile acid metabolism, antivirus process, and inflammatory response has been largely disclosed. This review is aimed at revealing these functions and underlying mechanisms of 25-HC.

摘要

作为一种必需脂质，胆固醇在维持细胞内稳态、作为胆汁酸和类固醇激素的前体以及稳定膜脂筏方面具有重要价值。作为通过酶促或自由基过程产生的一种胆固醇代谢产物，氧化甾醇在过去几十年中备受关注。其中，25-羟基胆固醇（25-HC）在胆固醇和胆汁酸代谢、抗病毒过程及炎症反应中的作用已被大量揭示。本综述旨在揭示25-HC的这些功能及其潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c0/7695496/60715bdcc930/OMCL2020-8893305.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c0/7695496/f64c75982e67/OMCL2020-8893305.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c0/7695496/2acd52516c9b/OMCL2020-8893305.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c0/7695496/e5492240c1ca/OMCL2020-8893305.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c0/7695496/60715bdcc930/OMCL2020-8893305.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c0/7695496/f64c75982e67/OMCL2020-8893305.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c0/7695496/2acd52516c9b/OMCL2020-8893305.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c0/7695496/e5492240c1ca/OMCL2020-8893305.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c0/7695496/60715bdcc930/OMCL2020-8893305.004.jpg

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