Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China; Department of Infectious Diseases, The General Hospital of Western Theater Command, Chengdu, Sichuan, 610083, China.
Intensive Care Unit, Chongqing Public Health Medical Center, Chongqing, 400036, China.
Virology. 2021 Jan 15;553:131-134. doi: 10.1016/j.virol.2020.11.012. Epub 2020 Nov 28.
In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals.
在同时感染 SARS-CoV-2 和 HBV 的患者中，肝损伤很常见。然而，SARS-CoV-2 和 HBV 合并感染之间的相互作用尚不清楚。先前队列中的 67 例 COVID-19 患者被纳入并分为 2 组（7 例 HBsAg+和 60 例 HBsAg-）。分析了 HBV 和 SARS-CoV-2 相关标志物的相关性。在 SARS-CoV-2 感染的急性期，HBV 复制标志物在 SARS-CoV-2 感染期间没有广泛波动。HBV 合并感染并没有延长 SARS-CoV-2 的病毒脱落周期或潜伏期。SARS-CoV-2 对慢性 HBV 感染动态的影响似乎不明显。SARS-CoV-2 感染不会成为这些个体中 HBV 再激活的源头。
