SARS-CoV-2 合并感染对慢性乙型肝炎感染的动力学无明显影响。
Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection.
机构信息
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China; Department of Infectious Diseases, The General Hospital of Western Theater Command, Chengdu, Sichuan, 610083, China.
Intensive Care Unit, Chongqing Public Health Medical Center, Chongqing, 400036, China.
出版信息
Virology. 2021 Jan 15;553:131-134. doi: 10.1016/j.virol.2020.11.012. Epub 2020 Nov 28.
In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals.
在同时感染 SARS-CoV-2 和 HBV 的患者中，肝损伤很常见。然而，SARS-CoV-2 和 HBV 合并感染之间的相互作用尚不清楚。先前队列中的 67 例 COVID-19 患者被纳入并分为 2 组（7 例 HBsAg+和 60 例 HBsAg-）。分析了 HBV 和 SARS-CoV-2 相关标志物的相关性。在 SARS-CoV-2 感染的急性期，HBV 复制标志物在 SARS-CoV-2 感染期间没有广泛波动。HBV 合并感染并没有延长 SARS-CoV-2 的病毒脱落周期或潜伏期。SARS-CoV-2 对慢性 HBV 感染动态的影响似乎不明显。SARS-CoV-2 感染不会成为这些个体中 HBV 再激活的源头。
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