Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing 100864, China.
J Asian Nat Prod Res. 2021 Sep;23(9):884-891. doi: 10.1080/10286020.2020.1791096. Epub 2020 Jul 13.
7β,8β-epoxy-(22,24)-24-methylcholesta-4,22-diene-3,6-dione (), a new steroid, along with five known analogues (-), was isolated from the deep sea-derived fungus, SD-311. Strikingly, possessed a rare 7,8-epoxidation moiety. Meanwhile, this is the first time to report natural products from this fungus species. The structures were established by extensive spectroscopic analysis. The absolute configuration was determined by X-ray diffraction experiments. Compound showed antibacterial activity against with MIC value of 32.0 µg/mL, while displayed inhibitions against and with MIC values both of 16 µg/mL.
7β,8β-环氧-(22,24)-24-甲基胆甾-4,22-二烯-3,6-二酮（），一种新的甾体化合物，与五种已知类似物（-）一起，从深海来源的真菌 SD-311 中分离得到。引人注目的是，拥有罕见的 7,8-环氧化部分。同时，这是首次从该真菌物种中报道天然产物。结构通过广泛的光谱分析确定。绝对构型通过 X 射线衍射实验确定。化合物对具有 MIC 值为 32.0 μg/mL 的抗菌活性，而对和具有 MIC 值均为 16 μg/mL 的抑制活性。
