Komissarenko V P, Bezdrobnyĭ Iu V, Opanasiuk N D, Evdokimova N Iu, Efimov A S
Biull Eksp Biol Med. 1982 May;93(5):52-5.
A study was made of the effect of experimental hyperinsulinemia, caused by daily administration of the increasing doses of a crystalline insulin-zinc suspension (up to 6 Units per animal) during 14 days, on the parameters of 125I-insulin binding by the insulin receptors of plasma membranes of adipose and liver tissues of intact rats and those with disturbed liver innervation. In intact rats, hyperinsulinemia led to the fall of the concentration of the insulin receptors and their affinity for insulin in the membranes of both tissues. In rats with disturbed liver innervation, analogous changes were observed for the receptors of adipose tissue, whereas the parameters of the receptors of liver were unchanged under the effect of hyperinsulinemia. It is concluded that nerve fibers that innervate the liver take part in the regulation of activity of the insulin receptors.
进行了一项研究，观察连续14天每日给予递增剂量的结晶胰岛素锌悬液（每只动物最高达6单位）所引起的实验性高胰岛素血症，对完整大鼠以及肝神经支配受干扰大鼠的脂肪组织和肝组织质膜胰岛素受体结合125I胰岛素参数的影响。在完整大鼠中，高胰岛素血症导致两种组织膜中胰岛素受体浓度及其对胰岛素的亲和力下降。在肝神经支配受干扰的大鼠中，脂肪组织受体出现类似变化，而高胰岛素血症作用下肝受体参数未改变。得出的结论是，支配肝脏的神经纤维参与胰岛素受体活性的调节。
