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基于中国人群队列研究的列线图预测妊娠期糖尿病风险的模型。

Risk prediction model of gestational diabetes mellitus based on nomogram in a Chinese population cohort study.

机构信息

Department of Endocrinology, Peking University International Hospital, Beijing, China.

Department of Endocrinology, Beijing Jishuitan Hospital, Beijing, China.

出版信息

Sci Rep. 2020 Dec 4;10(1):21223. doi: 10.1038/s41598-020-78164-x.

Abstract

To build a risk prediction model of gestational diabetes mellitus using nomogram to provide a simple-to-use clinical basis for the early prediction of gestational diabetes mellitus (GDM). This study is a prospective cohort study including 1385 pregnant women. (1) It is showed that the risk of GDM in women aged ≥ 35 years was 5.5 times higher than that in women aged < 25 years (95% CI: 1.27-23.73, p < 0.05). In the first trimester, the risk of GDM in women with abnormal triglyceride who were in their first trimester was 2.1 times higher than that of lipid normal women (95% CI: 1.12-3.91, p < 0.05). The area under the ROC curve of the nomogram of was 0.728 (95% CI: 0.683-0.772), the sensitivity and specificity of the model were 0.716 and 0.652, respectively. This study provides a simple and economic nomogram for the early prediction of GDM risk in the first trimester, and it has certain accuracy.

摘要

建立基于列线图的妊娠期糖尿病风险预测模型,为妊娠期糖尿病(GDM)的早期预测提供一种简单易用的临床依据。本研究为前瞻性队列研究,纳入 1385 名孕妇。(1)结果显示,年龄≥35 岁的孕妇发生 GDM 的风险是年龄<25 岁孕妇的 5.5 倍(95%CI:1.27-23.73,p<0.05)。在早孕期,甘油三酯异常的孕妇发生 GDM 的风险是血脂正常孕妇的 2.1 倍(95%CI:1.12-3.91,p<0.05)。列线图模型的 ROC 曲线下面积为 0.728(95%CI:0.683-0.772),模型的灵敏度和特异度分别为 0.716 和 0.652。本研究为早孕期 GDM 风险的早期预测提供了一种简单、经济的列线图,具有一定的准确性。

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