Division of Infectious Disease and Immune Defense, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.
Mol Microbiol. 2021 May;115(5):916-929. doi: 10.1111/mmi.14661. Epub 2020 Dec 28.
Toxoplasma and other apicomplexan parasites undergo a unique form of cellular locomotion referred to as "gliding motility." Gliding motility is crucial for parasite survival as it powers tissue dissemination, host cell invasion and egress. Distinct environmental cues lead to activation of gliding motility and have become a prominent focus of recent investigation. Progress has been made toward understanding what environmental cues are sensed and how these signals are transduced in order to regulate the machinery and cellular events powering gliding motility. In this review, we will discuss new findings and integrate these into our current understanding to propose a model of how environmental sensing is achieved to regulate gliding motility in Toxoplasma. Collectively, these findings also have implications for the understanding of gliding motility across Apicomplexa more broadly.
刚地弓形虫和其他顶复门寄生虫经历一种独特的细胞运动形式，称为“滑行运动”。滑行运动对于寄生虫的生存至关重要，因为它为组织传播、宿主细胞入侵和逸出提供动力。不同的环境线索会导致滑行运动的激活，这已成为最近研究的一个重点。人们已经在理解哪些环境线索被感知以及这些信号如何转导以调节滑行运动的机械和细胞事件方面取得了进展。在这篇综述中，我们将讨论新的发现，并将这些发现整合到我们目前的理解中，提出一个关于如何通过环境感应来调节刚地弓形虫滑行运动的模型。总的来说，这些发现也对理解广泛的顶复门寄生虫的滑行运动有影响。
