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采用 Xpert MTB/RIF® 方法诊断皮肤结核（淋巴结瘰疬）。

Diagnosis of cutaneous tuberculosis (lymph node scrofuloderma) using the Xpert MTB/RIF® method.

机构信息

Dermatology Clinic, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.

Dermatology Clinic, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.

出版信息

An Bras Dermatol. 2021 Jan-Feb;96(1):82-84. doi: 10.1016/j.abd.2020.01.009. Epub 2020 Nov 19.

DOI:10.1016/j.abd.2020.01.009
PMID:33279316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7838117/
Abstract

Cutaneous tuberculosis is a rare infection that is difficult to diagnose, because it shows less sensitivity and specificity in classic complementary exams when compared with the pulmonary form. The Xpert MTB/RIF® method offers an early diagnosis that identifies the DNA of Mycobacterium tuberculosis and the main mutations that give the bacterium resistance to rifampicin. The authors present a case of scrofuloderma whose diagnosis was quickly obtained through the secretion of a cervical lesion, allowing an early diagnosis and the initiation of appropriate treatment.

摘要

皮肤结核是一种罕见的感染，难以诊断，因为与肺结核形式相比，其在经典的补充检查中显示出较低的敏感性和特异性。Xpert MTB/RIF® 方法提供了一种早期诊断，可以识别结核分枝杆菌的 DNA 以及导致细菌对利福平产生耐药性的主要突变。作者介绍了一例颈部病变分泌物迅速确诊的瘰疬病例，这有助于早期诊断和开始适当的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ff9/7838117/95690e847ec2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ff9/7838117/0ea06c2dd702/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ff9/7838117/444c8c65077a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ff9/7838117/95690e847ec2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ff9/7838117/0ea06c2dd702/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ff9/7838117/444c8c65077a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ff9/7838117/95690e847ec2/gr3.jpg

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Assessment of Extrapulmonary Tuberculosis Using Gene Xpert MTB/RIF Assay and Fluorescent Microscopy and Its Risk Factors at Dessie Referral Hospital, Northeast Ethiopia.采用 Gene Xpert MTB/RIF 检测和荧光显微镜法评估埃塞俄比亚东北部德西转诊医院的肺外结核病及其危险因素。
Biomed Res Int. 2018 Aug 7;2018:8207098. doi: 10.1155/2018/8207098. eCollection 2018.
2
Gene Xpert MTB/RIF assay for the diagnosis of intra-ocular tuberculosis from vitreous fluid samples.用于从玻璃体液样本中诊断眼内结核的Gene Xpert MTB/RIF检测
Tuberculosis (Edinb). 2017 Jan;102:1-2. doi: 10.1016/j.tube.2016.11.002. Epub 2016 Nov 4.
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Acta Derm Venereol. 2022 Jan 4;102:adv00622. doi: 10.2340/actadv.v101.335.
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Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria.自噬作为抗分枝杆菌皮肤感染药物研发的靶点
Front Immunol. 2021 May 25;12:674241. doi: 10.3389/fimmu.2021.674241. eCollection 2021.
Evaluation of GeneXpert MTB/RIF for detection of Mycobacterium tuberculosis complex and rpo B gene in respiratory and non-respiratory clinical specimens at a tertiary care teaching hospital in Saudi Arabia.
在沙特阿拉伯一家三级护理教学医院，对GeneXpert MTB/RIF用于检测呼吸道和非呼吸道临床标本中结核分枝杆菌复合群及rpo B基因的评估。
Saudi Med J. 2016 Dec;37(12):1404-1407. doi: 10.15537/smj.2016.12.15506.
4
Diagnostic accuracy of the Xpert MTB/RIF assay for extrapulmonary and pulmonary tuberculosis when testing non-respiratory samples: a systematic review.检测非呼吸道样本时，Xpert MTB/RIF检测法对肺外和肺结核的诊断准确性：一项系统评价
BMC Infect Dis. 2014 Dec 31;14:709. doi: 10.1186/s12879-014-0709-7.
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Cutaneous tuberculosis: diagnosis, histopathology and treatment - part II.皮肤结核：诊断、组织病理学与治疗 - 第二部分
An Bras Dermatol. 2014 Jul-Aug;89(4):545-55. doi: 10.1590/abd1806-4841.20142747.
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Cutaneous tuberculosis: epidemiologic, etiopathogenic and clinical aspects - part I.皮肤结核：流行病学、病因病理及临床方面——第一部分
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Xpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis: a systematic review and meta-analysis.Xpert MTB/RIF assay 检测在肺外结核诊断中的应用：系统评价与 Meta 分析。
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