Santos Josemir Belo dos, Figueiredo Ana Roberta, Ferraz Cláudia Elise, Oliveira Márcia Helena de, Silva Perla Gomes da, Medeiros Vanessa Lucília Sileira de
Universidade Federal de Pernambuco, Recife, PE, Brazil.
An Bras Dermatol. 2014 Jul-Aug;89(4):545-55. doi: 10.1590/abd1806-4841.20142747.
The evolution in the knowledge of tuberculosis' physiopathology allowed not only a better understanding of the immunological factors involved in the disease process, but also the development of new laboratory tests, as well as the establishment of a histological classification that reflects the host's ability to contain the infectious agent. At the same time, the increasing bacilli resistance led to alterations in the basic tuberculosis treatment scheme in 2009. This article critically examines laboratory and histological investigations, treatment regimens for tuberculosis and possible adverse reactions to the most frequently used drugs.
结核病病理生理学知识的发展不仅使人们对疾病过程中涉及的免疫因素有了更好的理解,还推动了新实验室检测方法的开发,以及建立了一种反映宿主控制感染因子能力的组织学分类。与此同时,结核菌耐药性的不断增加导致2009年基本结核病治疗方案发生了改变。本文批判性地审视了实验室和组织学研究、结核病治疗方案以及最常用药物可能产生的不良反应。