Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China.
Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.
J Cell Mol Med. 2021 Jan;25(2):919-924. doi: 10.1111/jcmm.16148. Epub 2020 Dec 6.
YKL-40 was reported to be associated with the risk of hypertension. Whether the variants of CHI3L1 gene were associated with both YKL-40 levels and hypertension needs to be further elucidated. In a 1:1 matched case-control study of 507 pairs with available YKL-40 levels and DNA samples nested in a prospective cohort of Chinese subjects, the 15 tag single nucleotide polymorphisms (SNPs) of CHI3L1 gene were genotyped. The levels of YKL-40 among different genotypes of each SNP were compared after false discovery rate adjustment. Multivariable conditional logistic regression analyses were used to explore the association between the genotypes and the risk of hypertension. Subjects with the genetic variants for rs10399931, rs1538372, rs2071580, rs2297839 and rs4950928 had lower YKL-40 levels. The genetic variant for rs10399805 was associated with higher YKL-40 level. Subjects with the genotype of GA/AA of rs10399805 had a 1.34-fold risk of hypertension compared with those with GG genotype in the total population (P = .05). Subjects with heterozygote/rare homozygote genotype of rs4950928 and rs2297839 both had a significantly lower risk of hypertension compared with those with major homozygote genotype among men. The ORs (95% CIs) were 0.46 (0.23-0.89) and 0.49 (0.26-0.91), respectively. The above three SNPs could significantly improve the accuracy of risk prediction for hypertension based on the conventional factors. The genotypes of rs10399805, rs4950928 and rs2297839 may hopefully become stable biomarkers for predicting the risk of hypertension.
YKL-40 被报道与高血压的风险相关。CHI3L1 基因的变异是否与 YKL-40 水平和高血压都相关，需要进一步阐明。在一项 1:1 匹配的病例对照研究中，共纳入了 507 对有 YKL-40 水平和 DNA 样本的病例对照，这些样本嵌套在中国人群的前瞻性队列研究中。对 CHI3L1 基因的 15 个标签单核苷酸多态性（SNP）进行基因分型。在经过错误发现率调整后，比较了每个 SNP 的不同基因型之间的 YKL-40 水平。使用多变量条件逻辑回归分析来探讨基因型与高血压风险之间的关系。rs10399931、rs1538372、rs2071580、rs2297839 和 rs4950928 的遗传变异与 YKL-40 水平降低相关。rs10399805 的遗传变异与 YKL-40 水平升高相关。与 GG 基因型相比，总体人群中 GA/AA 基因型的 rs10399805 基因型个体患高血压的风险增加 1.34 倍（P =.05）。杂合子/罕见纯合子基因型的 rs4950928 和 rs2297839 的个体患高血压的风险均显著低于主要纯合子基因型的个体，男性的 OR（95% CI）分别为 0.46（0.23-0.89）和 0.49（0.26-0.91）。上述三个 SNP 可以显著提高基于常规因素的高血压风险预测的准确性。rs10399805、rs4950928 和 rs2297839 的基因型可能有望成为预测高血压风险的稳定生物标志物。
