Hong Guo-Qing, Cai Dong, Gong Jian-Ping, Lai Xing
Department of Hepatobiliary and Thyroid Breast Surgery, Tongnan District People's Hospital, Chongqing 402660, P.R. China.
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China.
Oncol Lett. 2021 Jan;21(1):57. doi: 10.3892/ol.2020.12319. Epub 2020 Nov 19.
Hepatocellular carcinoma (HCC) is a malignant tumor and is associated with necroinflammation driven by various immune cells, such as dendritic cells, macrophages and natural killer cells. Innate immune cells can directly affect HCC or regulate the T-cell responses that mediate HCC. In addition, innate immune cells and T cells are not isolated, which means the interaction between them is important in the HCC microenvironment. Considering the current unsatisfactory efficacy of immunotherapy in patients with HCC, understanding the relationship between innate immune cells and T cells is necessary. In the present review the roles and clinical value of innate immune cells that have been widely reported to be involved in HCC, including dendritic cells, macrophages (including kupffer cells), neutrophils, eosinophils, basophils and innate lymphoid cells and the crosstalk between the innate and adaptive immune responses in the antitumor process have been discussed. The present review will facilitate researchers in understanding the importance of innate immune cells in HCC and lead to innovative immunotherapy approaches for the treatment of HCC.
肝细胞癌（HCC）是一种恶性肿瘤，与由多种免疫细胞（如树突状细胞、巨噬细胞和自然杀伤细胞）驱动的坏死性炎症相关。固有免疫细胞可直接影响HCC或调节介导HCC的T细胞反应。此外，固有免疫细胞和T细胞并非孤立存在，这意味着它们之间的相互作用在HCC微环境中很重要。鉴于目前HCC患者免疫治疗的疗效不尽人意，了解固有免疫细胞与T细胞之间的关系很有必要。在本综述中，讨论了广泛报道的参与HCC的固有免疫细胞的作用和临床价值，包括树突状细胞、巨噬细胞（包括库普弗细胞）、中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞和固有淋巴细胞，以及抗肿瘤过程中固有免疫反应和适应性免疫反应之间的相互作用。本综述将有助于研究人员了解固有免疫细胞在HCC中的重要性，并为HCC的治疗带来创新的免疫治疗方法。
