Adlhoch Cornelia, Fusaro Alice, Gonzales José L, Kuiken Thijs, Marangon Stefano, Niqueux Éric, Staubach Christoph, Smietanka Krzysztof, Terregino Calogero, Van der Stede Yves, Aznar Inma, Baldinelli Francesca
EFSA J. 2020 Nov 24;18(11):e06341. doi: 10.2903/j.efsa.2020.6341. eCollection 2020 Nov.
Since 16 October 2020, outbreaks ofhighly pathogenic avian influenza (HPAI) viruseshavebeen reported inseveral EU/EEAcountries -Belgium, Denmark, France, Germany, Ireland, the Netherlands, and Swedenas well asin the United Kingdom.As of 19 November,12pm, 302 HPAI A(H5) detections have been reported, with the majority of the detections referring to wild birds (n=281), and a few related to outbreaks in poultry (n=18) and captive birds (n=3). Most of the detections in wild birds were in wild waterbirds,being barnacle goose the most affected species (n=110), followed by greylag goose (n=47), Eurasian wigeon (n=32),mallard (n=14), and common buzzard (n=13).ThreeHPAI virus subtypes were identified, A(H5N8), A(H5N5) and A(H5N1), with A(H5N8) being the most reported subtype (n=284). Phylogenetic analysis indicated that the viruses evolved from a single progenitor virus thatwent through multiple reassortment events. Based on the ongoing autumn migration of wild waterbirds to their wintering areas in Europe, there is a continued risk of further introduction of HPAI A(H5) viruses into Europe. Furthermore, given the expected movements of both migratory, and resident wild birds in Europe during winter, there is a high risk of further spread of HPAI A(H5) viruses within Europe. No genetic markers indicating adaptation to mammals have been identified in the viruses analysed so far,andno human infection due to avian influenza viruses detected in the recent outbreakshas been reported. For that reason,the risk to the general population remains very low.However,following the precautionary principle, people should avoid touching sick or dead birds unprotected to minimise any potential risk.
自2020年10月16日以来,欧盟/欧洲经济区的几个国家——比利时、丹麦、法国、德国、爱尔兰、荷兰、瑞典以及英国均报告了高致病性禽流感(HPAI)病毒疫情。截至11月19日中午12点,已报告302起HPAI A(H5)病毒检测事件,其中大部分检测涉及野生鸟类(n = 281),少数与家禽疫情(n = 18)和圈养鸟类疫情(n = 3)有关。野生鸟类中的大多数检测事件发生在野生水鸟身上,受影响最严重的物种是黑雁(n = 110),其次是灰雁(n = 47)、赤颈鸭(n = 32)、绿头鸭(n = 14)和普通鵟(n = 13)。已鉴定出三种HPAI病毒亚型,即A(H5N8)、A(H5N5)和A(H5N1),其中A(H5N8)是报告最多的亚型(n = 284)。系统发育分析表明,这些病毒由一种单一的祖源病毒进化而来,该祖源病毒经历了多次重配事件。基于野生水鸟秋季持续向欧洲越冬地迁徙的情况,HPAI A(H5)病毒进一步传入欧洲的风险依然存在。此外,考虑到欧洲冬季候鸟和留鸟的预期活动情况,HPAI A(H5)病毒在欧洲境内进一步传播的风险很高。在迄今为止分析的病毒中,尚未发现表明对哺乳动物具有适应性的基因标记,近期疫情中也未报告有人感染禽流感病毒。因此,对普通人群的风险仍然很低。然而,根据预防原则,人们应避免在无防护措施的情况下接触病禽或死禽,以将任何潜在风险降至最低。