Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan 430071, China.
Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115 MA, USA.
Oxid Med Cell Longev. 2020 Nov 17;2020:8871476. doi: 10.1155/2020/8871476. eCollection 2020.
Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by various intra- and extrapulmonary injury factors. Presently, excessive inflammation in the lung and the apoptosis of alveolar epithelial cells are considered to be the key factors in the pathogenesis of ALI. Hypoxia-inducible factor-1 (HIF-1) is an oxygen-dependent conversion activator that is closely related to the activity of reactive oxygen species (ROS). HIF-1 has been shown to play an important role in ALI and can be used as a potential therapeutic target for ALI. This manuscript will introduce the progress of HIF-1 in ALI and explore the feasibility of applying inhibitors of HIF-1 to ALI, which brings hope for the treatment of ALI.
急性肺损伤（ALI）是由各种肺内和肺外损伤因素引起的急性低氧性呼吸功能不全。目前，认为肺内过度炎症和肺泡上皮细胞凋亡是 ALI 发病机制中的关键因素。缺氧诱导因子-1（HIF-1）是一种与活性氧（ROS）密切相关的氧依赖性转换激活剂。研究表明，HIF-1 在 ALI 中发挥着重要作用，可作为 ALI 的潜在治疗靶点。本文将介绍 HIF-1 在 ALI 中的研究进展，并探讨应用 HIF-1 抑制剂治疗 ALI 的可行性，为 ALI 的治疗带来希望。
