Ghafaryasl Babak, Vermeer Koenraad A, Kalkman Jeroen, Callewaert Tom, de Boer Johannes F, Van Vliet Lucas J
Rotterdam Ophthalmic Institute, Rotterdam Eye Hospital, Rotterdam, 3011 BH, The Netherlands.
Department of Imaging Physics, Delft University of Technology, Delft, 2628 BL, The Netherlands.
Biomed Opt Express. 2020 Oct 6;11(11):6093-6107. doi: 10.1364/BOE.403283. eCollection 2020 Nov 1.
The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an OCT signal in a homogenous sample to the recorded OCT signal. In addition, we employ numerical analysis to obtain the theoretical optimal precision of the estimated parameters for different experimental setups. Finally, the method is applied to OCT B-scans obtained from homogeneous samples. The numerical and experimental results show accurate estimations of the AC and the focus location when the focus is located inside the sample.
衰减系数（AC）是组织的一种光学特性，可从光学相干断层扫描（OCT）数据中估算得出。在本文中，我们旨在通过补偿聚焦光束的形状来准确估算AC。为此，我们提出了一种方法，通过将均匀样本中OCT信号的模型拟合到记录的OCT信号来估算轴向点扩散函数（PSF）模型参数和AC。此外，我们采用数值分析来获得不同实验设置下估计参数的理论最佳精度。最后，将该方法应用于从均匀样本获得的OCT B扫描图像。数值和实验结果表明，当焦点位于样本内部时，AC和焦点位置的估计是准确的。
