Ghafaryasl Babak, Vermeer Koenraad A, Kalkman Jeroen, Callewaert Tom, de Boer Johannes F, van Vliet Lucas J
Rotterdam Ophthalmic Institute, Rotterdam Eye Hospital, 3011 BH, Rotterdam, The Netherlands.
Department of Imaging Physics, Delft University of Technology, 2628 CJ, Delft, The Netherlands.
Biomed Opt Express. 2021 Apr 15;12(5):2744-2758. doi: 10.1364/BOE.415079. eCollection 2021 May 1.
Optical properties, such as the attenuation coefficients of multi-layer tissue samples, could be used as a biomarker for diagnosis and disease progression in clinical practice. In this paper, we present a method to estimate the attenuation coefficients in a multi-layer sample by fitting a single scattering model for the OCT signal to the recorded OCT signal. In addition, we employ numerical simulations to obtain the theoretically achievable precision and accuracy of the estimated parameters under various experimental conditions. Finally, the method is applied to two sets of measurements obtained from a multi-layer phantom by two experimental OCT systems: one with a large and one with a small Rayleigh length. Numerical and experimental results show an accurate estimation of the attenuation coefficients when using multiple B-scans.
光学特性，如多层组织样本的衰减系数，可作为临床实践中诊断和疾病进展的生物标志物。在本文中，我们提出了一种通过将光学相干断层扫描（OCT）信号的单散射模型拟合到记录的OCT信号来估计多层样本中衰减系数的方法。此外，我们采用数值模拟来获得在各种实验条件下估计参数理论上可达到的精度和准确性。最后，该方法应用于由两个实验性OCT系统从多层体模获得的两组测量数据：一个具有大瑞利长度，另一个具有小瑞利长度。数值和实验结果表明，使用多个B扫描时，衰减系数能够得到准确估计。
