Tay Hui Sian, Wood Adrian D, Carter Ben, Pearce Lyndsay, McCarthy Kathryn, Stechman Michael J, Myint Phyo K, Hewitt Jonathan
Department of Geriatric Medicine, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.
Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Front Surg. 2020 Nov 16;7:583653. doi: 10.3389/fsurg.2020.583653. eCollection 2020.
The impact of surgery compared to non-surgical management of older general surgical patients is not well researched. We examined the association between management and adverse outcomes in a cohort of emergency general surgery patients aged > 65 years. This multi-center study included 727 patients (mean+/-SD, 77.1 ± 8.2 years, 54% female) admitted to five UK hospitals. Data were analyzed using multi-level crude and multivariable logistic regression. Outcomes were: mortality at Day 30 and 90, length of stay, and readmission within 30 days of discharge. Covariates assessed were management approach, age, sex, frailty, polypharmacy, anemia, and hypoalbuminemia. Approximately 25% of participants ( = 185) underwent emergency surgery. Frailty and albumin were associated with mortality at 30 (frailty OR = 3.52 [95% CI 1.66-7.49], albumin OR = 3.78 ([95% CI 1.53-9.31]), and 90 days post discharge (frailty OR = 3.20 [95% CI 1.86-5.51], albumin OR=3.25 [95% CI 1.70-6.19]) and readmission (frailty OR = 1.56 [95% CI (1.04-2.35)]). Surgically managed patients and frailty had increased odds of prolonged hospitalization (surgery OR = 5.69 [95% CI 3.67-8.80], frailty OR = 2.17 [95% CI 1.46-3.23]). We found the impact of surgery on length of hospitalization in older surgical patients is substantial. Whether early comprehensive geriatric assessment and post-op rehabilitation would improve this outcome require further evaluation.
与非手术治疗相比,手术治疗对老年普通外科患者的影响尚未得到充分研究。我们在一组年龄大于65岁的急诊普通外科患者中,研究了治疗方式与不良结局之间的关联。这项多中心研究纳入了英国五家医院收治的727例患者(平均±标准差,77.1±8.2岁,54%为女性)。使用多水平粗逻辑回归和多变量逻辑回归分析数据。结局指标包括:30天和90天死亡率、住院时间以及出院后30天内再入院情况。评估的协变量包括治疗方式、年龄、性别、虚弱、多种药物治疗、贫血和低白蛋白血症。约25%的参与者(n = 185)接受了急诊手术。虚弱和白蛋白水平与出院后30天(虚弱比值比 = 3.52 [95%置信区间1.66 - 7.49],白蛋白比值比 = 3.78 [95%置信区间1.53 - 9.31])和90天死亡率(虚弱比值比 = 3.20 [95%置信区间1.86 - 5.51],白蛋白比值比 = 3.25 [95%置信区间1.70 - 6.19])以及再入院情况(虚弱比值比 = 1.56 [95%置信区间(1.04 - 2.35)])相关。接受手术治疗的患者和虚弱患者延长住院时间的几率增加(手术比值比 = 5.69 [95%置信区间3.67 - 8.80],虚弱比值比 = 2.17 [95%置信区间1.46 - 3.23])。我们发现手术对老年外科患者住院时间的影响很大。早期全面的老年医学评估和术后康复是否能改善这一结局需要进一步评估。