Laboratory of Experimental Pathophysiology (LAFEx), Department of Biological Sciences (DECBI), Institute of Exact and Biological Sciences (ICEB), Federal University of Ouro Preto (UFOP), 35400-000 Ouro Preto, MG, Brazil.
Laboratory of Immunobiology of Inflammation (LABIIN), Department of Biological Sciences (DECBI), Institute of Exact and Biological Sciences (ICEB), Federal University of Ouro Preto (UFOP), 35400-000 Ouro Preto, MG, Brazil.
Biomed Res Int. 2020 Nov 15;2020:2196207. doi: 10.1155/2020/2196207. eCollection 2020.
Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure.
香烟烟雾具有高度毒性，可促进活性氧物质和炎症反应的产生，从而导致肝脏疾病。槲皮素是一种类黄酮，在肝脏疾病中具有抗氧化和抗炎作用。本研究旨在评估槲皮素对长期暴露于香烟烟雾的小鼠肝脏的保护作用。雄性 C57BL/6 小鼠分为五组：对照组（CG）、载体组（VG）、槲皮素组（QG）、香烟烟雾组（CSG）、槲皮素和香烟烟雾组（QCSG）。CSG 和 QCSG 连续 60 天暴露于香烟烟雾中；暴露结束时，所有动物均被安乐死。与 CSG 相比，每天接受槲皮素并暴露于香烟烟雾的小鼠显示出炎症细胞浸润、氧化应激、炎症反应和肝脏组织病理学变化减少。这些结果表明，槲皮素可能是治疗香烟烟雾暴露引起的肝损伤的有效辅助药物。
