School of Medical Sciences, The University of Manchester, Manchester, UK.
Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia.
Early Interv Psychiatry. 2021 Dec;15(6):1575-1583. doi: 10.1111/eip.13096. Epub 2020 Nov 30.
Psychotic-like experiences (PLEs) are common in adolescents. Their persistence may confer increased susceptibility to psychotic disorder. The early evolution of transient to persistent PLEs is not well known. This study aimed to investigate the early persistence of PLEs (over 6-12 months) in a community sample of adolescents and examine baseline and longitudinal associations of early persistent PLEs.
Five hundred and ninety Year 10 students were administered the community assessment of psychic experiences (CAPE) to measure PLEs at baseline and at follow up 6-12 months later. Persistent PLEs were defined as those present at or above the 90th centile at both time points. Independent variables of depression, psychological distress and functioning were all measured at both baseline and follow up. Self-esteem, personality and suicidality were assessed at follow up.
The study found 5.1% of participants had early persistent PLEs. Persistence was associated positively with depression and distress at both time points, neuroticism and openness at baseline and suicidality at follow up. Persistence was negatively associated with functioning at both time points, agreeableness at baseline and self-esteem at follow-up. Only depression remained significantly associated at both time points when accounting for other variables. Thus, depressive symptoms may account for changes in other domains and be a predictor of early PLEs persistence.
These results reinforce the importance of monitoring and assessing PLEs in young people especially when associated with depression. Further research is required to investigate PLE persistence over longer periods with increased measurement intervals.
精神病样体验(PLEs)在青少年中很常见。它们的持续存在可能会增加患精神病的易感性。PLE 从短暂到持续的早期演变尚不清楚。本研究旨在调查社区青少年样本中 PLE 的早期持续性(6-12 个月以上),并检查早期持续性 PLE 的基线和纵向关联。
对 590 名 10 年级学生进行了社区心理体验评估(CAPE),以在基线和 6-12 个月后随访时测量 PLE。持续性 PLE 定义为在两个时间点均处于或高于第 90 百分位数的 PLE。抑郁、心理困扰和功能的独立变量均在基线和随访时进行测量。自尊、人格和自杀意念在随访时进行评估。
研究发现,5.1%的参与者存在早期持续性 PLE。持续性与两个时间点的抑郁和困扰、基线时的神经质和开放性以及随访时的自杀意念呈正相关。持续性与两个时间点的功能、基线时的宜人性以及随访时的自尊呈负相关。仅在考虑其他变量时,抑郁在两个时间点仍然与持续性显著相关。因此,抑郁症状可能会导致其他领域的变化,并成为早期 PLE 持续性的预测因素。
这些结果强调了监测和评估年轻人 PLE 的重要性,尤其是当 PLE 与抑郁相关时。需要进一步研究以在更长时间内并增加测量间隔来研究 PLE 的持续性。