测量昼夜节律相关操作对啮齿动物抑郁样行为的影响：强迫游泳和悬尾试验。
Measuring the Effects of Circadian Rhythm-Related Manipulations on Depression-Like Behavior in Rodents: Forced Swim and Tail Suspension Tests.
机构信息
Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Psychiatry and Clinical and Translational Science, Translational Neuroscience Program, Center for Neuroscience University of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
Methods Mol Biol. 2021;2130:69-78. doi: 10.1007/978-1-0716-0381-9_5.
Abstract
The forced swim and tail suspension tests are commonly used to determine the effects of circadian-related pharmacological, genetic, and environmental manipulations on depression-like behavior in rodents. Both tests involve scoring immobility of rodents in an inescapable condition. Here we describe how to set up and carry out these tests.
摘要
强迫游泳和悬尾试验常用于确定与昼夜节律相关的药理学、遗传学和环境操作对啮齿动物抑郁样行为的影响。这两种试验都涉及对处于不可逃脱状态的啮齿动物的不动行为进行评分。在此，我们将描述如何建立和进行这些试验。
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