Section of Vascular Surgery and Endovascular Therapy, Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, IL.
Section of Vascular Surgery and Endovascular Therapy, Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, IL.
Ann Vasc Surg. 2021 Apr;72:663.e9-663.e13. doi: 10.1016/j.avsg.2020.10.025. Epub 2020 Dec 4.
Demographics are shifting toward an increasingly older population in the United States; thus, it is imperative that patients with a complex cardiovascular history are approached in a systematic fashion. Currently, there is no clear protocol on how best to manage elderly patients who present with both severe coronary artery disease and symptomatic carotid stenosis. For cardiac patients with severe, asymptomatic, high-grade carotid artery stenosis, there may be even more of a conundrum. Although most centers would tend to manage the asymptomatic carotid stenosis expectantly, it is well known that patients with severe, uncorrected internal carotid artery disease are at an increased risk of experiencing a cerebrovascular accident during coronary artery bypass grafting (CABG). One approach that has been recognized in other settings as a cost-effective strategy to stabilize high-risk elderly patients preoperatively is the use of an intra-aortic balloon pump (IABP). To better understand the best approach to take in these patients with concomitant disease, we analyzed the outcomes of 4 patients who underwent placement of an IABP before carotid endarterectomy (CEA) as a bridge to CABG.
Between 2017 and 2019, 4 patients presented with multivessel symptomatic coronary artery disease and greater than 90% stenosis of at least one internal carotid artery and underwent either staged or simultaneous CEA and CABG. There was placement of an IABP in all patients before the CEA. Time to CABG ranged from a simultaneous procedure to 23 days after CEA.
The only death within 30-day postoperation involved the patient who had CEA and CABG performed simultaneously. None of the surviving patients experienced a myocardial infarction. Two of the 4 patients experienced acute kidney injury after surgery, and one patient developed atrial fibrillation postoperatively. None of the patients experienced a postoperative neurological complication. In addition, there were no access site complications associated with IABP placement.
A staged procedure with placement of an IABP can be successfully used in carefully selected patients presenting with concomitant severe carotid and coronary artery disease who will undergo surgical management of their disease. The stabilization provided by IABP was potentially protective against adverse postoperative events and appeared to allow for flexibility in the time between CEA to CABG for patients. Additional studies are necessary to further understand the impact of such an approach.
美国人口结构正逐渐向老龄化转变;因此,必须以系统的方式治疗有复杂心血管病史的患者。目前,对于同时患有严重冠状动脉疾病和有症状颈动脉狭窄的老年患者,尚无最佳治疗方案。对于有严重、无症状、高级别颈动脉狭窄的心脏患者,可能会更加棘手。虽然大多数中心倾向于期待性地治疗无症状颈动脉狭窄,但众所周知,严重、未经纠正的颈内动脉疾病患者在冠状动脉旁路移植术(CABG)期间发生脑血管意外的风险增加。在其他情况下,一种被认为是经济有效的策略,可以稳定高危老年患者术前状态的方法是使用主动脉内球囊泵(IABP)。为了更好地了解这些合并疾病患者的最佳治疗方法,我们分析了 4 例在颈动脉内膜切除术(CEA)前放置 IABP 作为 CABG 桥接的患者的结局。
在 2017 年至 2019 年期间,4 例患者患有多支血管有症状的冠状动脉疾病,至少一条颈内动脉狭窄超过 90%,并接受分期或同期 CEA 和 CABG。所有患者在 CEA 前均放置了 IABP。CABG 的时间从 CEA 后 23 天到同期手术不等。
术后 30 天内唯一的死亡病例涉及同期接受 CEA 和 CABG 的患者。存活患者均未发生心肌梗死。4 例患者中有 2 例术后发生急性肾损伤,1 例术后发生心房颤动。所有患者均未发生术后神经系统并发症。此外,IABP 放置无血管入路并发症。
对于同时患有严重颈动脉和冠状动脉疾病并将接受手术治疗的患者,分期手术联合 IABP 可成功使用。IABP 的稳定作用可能对术后不良事件具有保护作用,并为患者在 CEA 与 CABG 之间的时间提供了灵活性。需要进一步的研究来进一步了解这种方法的影响。