Tang Hua-Yu, Li Yu-Zhi, Tang Zhao-Chen, Wang Lu-Yao, Wang Tian-Shu, Araujo Fernando
Second Ward of Orthopedics Department.
Department of Urology, First Affiliated Hospital of Jiamusi University.
Medicine (Baltimore). 2020 May;99(19):e20169. doi: 10.1097/MD.0000000000020169.
The aim of this study is to evaluate the efficacy of neural stem cell transplantation (NSCT) for the treatment of patients with spinal cord injury (SCI).
All potential randomized controlled trials (RCTs) on NSCT in the treatment of patients with SCI will be searched from the following electronic databases: Cochrane Library, MEDILINE, EMBASE, Web of Science, Scopus, CBM, WANGFANG, and CNKI. We will search all electronic databases from their initiation to the January 31, 2020 in spite of language and publication date. Two contributors will independently select studies from all searched literatures, extract data from included trials, and evaluate study quality for all eligible RCTs using Cochrane risk of bias tool, respectively. Any confusion will be resolved by consulting contributor and a consensus will be reached. We will utilize RevMan 5.3 software to pool the data and to conduct the data analysis.
This study will summarize the most recent RCTs to investigate the efficacy and safety of NSCT in the treatment of patients with SCI.
This study will provide evidence to assess the efficacy and safety of NSCT in the treatment of patients with SCI at evidence-based medicine level.
PROSPERO CRD42020173792.
本研究旨在评估神经干细胞移植（NSCT）治疗脊髓损伤（SCI）患者的疗效。
将从以下电子数据库检索所有关于NSCT治疗SCI患者的潜在随机对照试验（RCT）：Cochrane图书馆、MEDILINE、EMBASE、科学网、Scopus、中国生物医学文献数据库、万方数据和中国知网。无论语言和发表日期如何，我们将检索所有电子数据库从创建到2020年1月31日的文献。两名研究人员将分别从所有检索到的文献中独立选择研究，从纳入试验中提取数据，并使用Cochrane偏倚风险工具评估所有符合条件的RCT的研究质量。如有任何疑问，将通过咨询研究人员解决并达成共识。我们将使用RevMan 5.3软件汇总数据并进行数据分析。
本研究将总结最新的RCT，以调查NSCT治疗SCI患者的疗效和安全性。
本研究将在循证医学层面提供证据，以评估NSCT治疗SCI患者的疗效和安全性。
PROSPERO CRD42020173792。
