Grasso Giuseppe, Mummolo Stefano, Bernardi Sara, Pietropaoli Davide, D'Ambrosio Giuseppe, Iezzi Giovanna, Piattelli Adriano, Bianchi Serena, Marchetti Enrico
Dentistry Service, Jewish Hospital, Via Fulda 14, 00148 Roma, Italy.
Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Materials (Basel). 2020 Dec 3;13(23):5520. doi: 10.3390/ma13235520.
This study aimed to investigate the histological features of deproteinized equine bone mineral (DEBM) and anorganic bovine bone (ABB) after human sinus augmentation with the lateral approach. Twenty-three sinus augmentations were performed in 16 patients (male: 10/female: 6) using DEBM or ABB in a randomized fashion. Healing took place over the next 6 months. Bone core biopsies (N = 23) were obtained for each subject prior to placing the dental implants. The biopsies were processed for both histological descriptions and histomorphometric analysis. Statistical analyses were applied as appropriate, defining statistical significance as < 0.05. Core bone biopsies revealed no differences in terms of newly formed bone between groups, or differences in terms of tissue inflammation. Both DEBM and ABB appear to be suitable biomaterials for bone augmentation in sinus lift surgery in the short term. However, dedicated studies are required to confirm these results and their stability in the long term.
本研究旨在探讨经外侧入路进行人类鼻窦增高术后脱蛋白马骨矿物质（DEBM）和无机牛骨（ABB）的组织学特征。16例患者（男性10例/女性6例）接受了23次鼻窦增高术，随机使用DEBM或ABB。在接下来的6个月内进行愈合。在植入牙种植体之前，为每个受试者获取骨芯活检样本（N = 23）。对活检样本进行组织学描述和组织形态计量分析。进行适当的统计分析，将统计学显著性定义为<0.05。骨芯活检显示，两组之间新形成骨方面无差异，组织炎症方面也无差异。短期内，DEBM和ABB似乎都是鼻窦提升手术中骨增量的合适生物材料。然而，需要专门的研究来证实这些结果及其长期稳定性。
