School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an 710061, China.
School of Mathematics, Northwest University, Xi'an 710127, China.
Int J Environ Res Public Health. 2020 Dec 3;17(23):9027. doi: 10.3390/ijerph17239027.
Several studies have reported that air pollution and climatic factors are major contributors to human morbidity and mortality globally. However, the combined interactive effects of air pollution and climatic factors on human health remain largely unexplored. This study aims to investigate the interactive effects of air pollution and climatic factors on circulatory and respiratory mortality in Xi'an, China. Time-series analysis and the distributed lag non-linear model (DLNM) were employed as the study design and core statistical method. The interaction relative risk (IRR) and relative excess risk due to interaction (RERI) for temperature and Air Quality Index (AQI) interaction on circulatory mortality were 0.973(0.969, 0.977) and -0.055(-0.059, -0.048), respectively; while for relative humidity and AQI interaction, 1.098(1.011, 1.072) and 0.088(0.081, 0.107) respectively, were estimated. Additionally, the IRR and RERI for temperature and AQI interaction on respiratory mortality were 0.805(0.722, 0.896) and -0.235(-0.269, -0.163) respectively, while 1.008(0.965, 1.051) and -0.031(-0.088, 0.025) respectively were estimated for relative humidity and AQI interaction. The interaction effects of climatic factors and AQI were synergistic and antagonistic in relation to circulatory and respiratory mortality, respectively. Interaction between climatic factors and air pollution contributes significantly to circulatory and respiratory mortality.
多项研究报告称，空气污染和气候因素是导致全球人类发病率和死亡率的主要因素。然而，空气污染和气候因素对人类健康的综合交互影响在很大程度上仍未得到探索。本研究旨在探讨空气污染和气候因素对中国西安循环系统和呼吸系统死亡率的交互影响。时间序列分析和分布式滞后非线性模型（DLNM）被用作研究设计和核心统计方法。温度和空气质量指数（AQI）交互作用对循环系统死亡率的交互相对风险（IRR）和交互超额相对风险（RERI）分别为 0.973（0.969，0.977）和-0.055（-0.059，-0.048）；而对于相对湿度和 AQI 交互作用，估计值分别为 1.098（1.011，1.072）和 0.088（0.081，0.107）。此外，温度和 AQI 交互作用对呼吸系统死亡率的 IRR 和 RERI 分别为 0.805（0.722，0.896）和-0.235（-0.269，-0.163），而相对湿度和 AQI 交互作用的估计值分别为 1.008（0.965，1.051）和-0.031（-0.088，0.025）。气候因素和 AQI 之间的交互作用对循环系统和呼吸系统死亡率分别具有协同和拮抗作用。气候因素和空气污染之间的相互作用对循环系统和呼吸系统死亡率有显著贡献。
